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ChemicalBook >> CAS DataBase List >>FLT3-IN-3

FLT3-IN-3

CAS No.
2229050-90-0
Chemical Name:
FLT3-IN-3
Synonyms
SAN50900;FLT3-IN-3;FLT3-IN-3, 10 mM in DMSO;N2-(trans-4-Aminocyclohexyl)-9-cyclopentyl-N6-(4-(morpholinomethyl)phenyl)-9H-purine-2,6-diamine;9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-;9-cyclopentyl-N6-{4-[(morpholin-4-yl)methyl]phenyl}-N2-[(1r,4r)-4-aminocyclohexyl]-9H-purine-2,6-diamine;inhibit,Fms like tyrosine kinase 3,FLT-3-IN-3,FLT3,CD135,Inhibitor,Cluster of differentiation antigen 135,FLT3IN3,FLT3 IN 3
CBNumber:
CB25540576
Molecular Formula:
C27H38N8O
Molecular Weight:
490.64
MDL Number:
MFCD31813658
MOL File:
2229050-90-0.mol
Last updated:2025-04-18 09:51:56

FLT3-IN-3 Properties

Boiling point 717.6±70.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): insol
form A solid
pka 10.42±0.70(Predicted)
color White to off-white

FLT3-IN-3 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0043484 FLT3-IN-3 99.73% 2229050-90-0 5mg $400 2021-12-16 Buy
DC Chemicals DC44219 FLT3-IN-3 >98% 2229050-90-0 100mg $650 2021-12-16 Buy
Product number Packaging Price Buy
CS-0043484 5mg $400 Buy
DC44219 100mg $650 Buy

FLT3-IN-3 Chemical Properties,Uses,Production

Uses

FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively.

in vivo

A single dose of FLT3-IN-3 (Compound 7d; 10 mg/kg; i.p.) in mice with subcutaneous MV4-11 xenografts causes sustained inhibition of FLT3 and STAT5 phosphorylation over 48 hours[1].

Animal Model:Female athymic nu/nu mice with subcutaneously implanted MV4-11 xenografts[1]
Dosage:10 mg/kg
Administration:Intraperitoneal (i.p.) injection; 48 hours
Result:Effectively inhibited FLT3-ITD autophosphorylation in MV4-11 xenografts.

References

[1] Gucky T, et al. Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations. J Med Chem. 2018 May 10;61(9):3855-3869. DOI:10.1021/acs.jmedchem.7b01529

FLT3-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

FLT3-IN-3 Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32275 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4610 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 6448 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62

View Lastest Price from FLT3-IN-3 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
FLT3-IN-3 pictures 2024-11-19 FLT3-IN-3
2229050-90-0
 US $109.00-455.00 / mg 99.25% 10g TargetMol Chemicals Inc.
FLT3-IN-3 pictures 2024-11-19 FLT3-IN-3
2229050-90-0
 US $109.00-455.00 / mg 99.25% 10g TargetMol Chemicals Inc.
  • FLT3-IN-3 pictures
  • FLT3-IN-3
    2229050-90-0
  • US $109.00-455.00 / mg
  • 99.25%
  • TargetMol Chemicals Inc.
  • FLT3-IN-3 pictures
  • FLT3-IN-3
    2229050-90-0
  • US $109.00-455.00 / mg
  • 99.25%
  • TargetMol Chemicals Inc.

FLT3-IN-3 Spectrum

FLT3-IN-3 9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]- SAN50900 inhibit,Fms like tyrosine kinase 3,FLT-3-IN-3,FLT3,CD135,Inhibitor,Cluster of differentiation antigen 135,FLT3IN3,FLT3 IN 3 N2-(trans-4-Aminocyclohexyl)-9-cyclopentyl-N6-(4-(morpholinomethyl)phenyl)-9H-purine-2,6-diamine 9-cyclopentyl-N6-{4-[(morpholin-4-yl)methyl]phenyl}-N2-[(1r,4r)-4-aminocyclohexyl]-9H-purine-2,6-diamine FLT3-IN-3, 10 mM in DMSO 2229050-90-0 C27H38N8O