Tarloxotinib bromide
- CAS No.
- 1636180-98-7
- Chemical Name:
- Tarloxotinib bromide
- Synonyms
- PR610;TH4000;PR 610;PR-610;TH-4000;Hypoxin;TH 4000;Tarloxotinib bromide;Tarloxotinib bromide,PR-610;Tarloxotinib bromide, 10 mM in DMSO
- CBNumber:
- CB23165809
- Molecular Formula:
- C24H24Br2ClN9O3
- Molecular Weight:
- 681.77
- MDL Number:
- MFCD30533434
- MOL File:
- 1636180-98-7.mol
storage temp. | Store at -20°C |
---|---|
solubility | DMSO:30.0(Max Conc. mg/mL);44.0(Max Conc. mM) |
form | Solid |
color | Light yellow to yellow |
FDA UNII | 3Y31FJ8K50 |
NCI Drug Dictionary | Hypoxin |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Tarloxotinib bromide price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | T007610 | TarloxotinibBromide | 1636180-98-7 | 10mg | $1320 | 2021-12-16 | Buy |
ChemScene | CS-0016823 | Tarloxotinib(bromide) 98.97% | 1636180-98-7 | 25mg | $1500 | 2021-12-16 | Buy |
ChemScene | CS-0016823 | Tarloxotinib(bromide) 98.97% | 1636180-98-7 | 50mg | $2100 | 2021-12-16 | Buy |
ChemScene | CS-0016823 | Tarloxotinib(bromide) 98.97% | 1636180-98-7 | 100mg | $3300 | 2021-12-16 | Buy |
ChemScene | CS-0016823 | Tarloxotinib(bromide) 98.97% | 1636180-98-7 | 5mg | $450 | 2021-12-16 | Buy |
Tarloxotinib bromide Chemical Properties,Uses,Production
Uses
Tarloxotinib Bromide is a kinase inhibitor prodrug useful in the treatment of cancer.
in vivo
A prototypic WT EGFR driven xenograft model (A431) is used to benchmark Tarloxotinib bromide activity against each EGFR-TKI by “retrotranslation” of reported plasma exposure for each agent in human subjects back to the xenograft model. Only treatment with clinically relevant doses and schedules of Tarloxotinib bromide is associated with tumor regression and durable inhibition of WT EGFR tumor phosphorylation. Consistent with these findings, Tarloxotinib bromide treatment can also regress the WT EGFR NSCLC tumor models H125 and H1648, demonstrating Tarloxotinib bromide provides the necessary therapeutic index to inhibit WT EGFR in vivo[1].
IC 50
EGFR/HER2
Tarloxotinib bromide Preparation Products And Raw materials
Raw materials
Preparation Products
Tarloxotinib bromide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32275 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3467 | 58 |
Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 | shenlinxing@macklin.cn | China | 15874 | 55 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
Shanghai Chaolan Chemical Technology Center | 021-QQ:65489617 15618227136 | Sales@ATKchemical.com | China | 9348 | 58 |
Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10123 | 58 |
View Lastest Price from Tarloxotinib bromide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2025-05-02 | Tarloxotinib bromide
1636180-98-7
|
US $143.00-455.00 / mg | 97.15% | 10g | TargetMol Chemicals Inc. | ||
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2025-04-30 | Tarloxotinib bromide
1636180-98-7
|
US $143.00-455.00 / mg | 97.15% | 10g | TargetMol Chemicals Inc. |
-
- Tarloxotinib bromide
1636180-98-7
- US $143.00-455.00 / mg
- 97.15%
- TargetMol Chemicals Inc.
-
- Tarloxotinib bromide
1636180-98-7
- US $143.00-455.00 / mg
- 97.15%
- TargetMol Chemicals Inc.