IBTP ((4-Iodobutyl)triphenylphosphonium)
- CAS No.
- 159085-21-9
- Chemical Name:
- IBTP ((4-Iodobutyl)triphenylphosphonium)
- Synonyms
- IBTP (iodide);4-iodobutyl(triphenyl)phosphanium;IBTP ((4-Iodobutyl)triphenylphosphonium);(4-Iodobutyl)(triphenyl)phosphanium iodide;Phosphonium, (4-iodobutyl)triphenyl-, iodide (1:1);IBTP ((4-Iodobutyl)triphenylphosphonium), mitochondrial thiol-specific cationic alkylation reagent
- CBNumber:
- CB23152951
- Molecular Formula:
- C22H23I2P
- Molecular Weight:
- 572.21
- MDL Number:
- MFCD06411422
- MOL File:
- 159085-21-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
IBTP ((4-Iodobutyl)triphenylphosphonium) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18802 | IBTP (iodide) ≥98% | 159085-21-9 | 5mg | $51 | 2024-03-01 | Buy |
| Cayman Chemical | 18802 | IBTP (iodide) ≥98% | 159085-21-9 | 10 mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 18802 | IBTP (iodide) ≥98% | 159085-21-9 | 25mg | $229 | 2024-03-01 | Buy |
| AK Scientific | 9477CW | (4-Iodobutyl)(triphenyl)phosphaniumiodide | 159085-21-9 | 5mg | $147 | 2021-12-16 | Buy |
IBTP ((4-Iodobutyl)triphenylphosphonium) Chemical Properties,Uses,Production
Description
IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner.1 As a result, mitochondrial proteins that have changed thiol redox state following oxidative stress are selectively tagged with IBTP and can be separated by two-dimensional electrophoresis and isolated.1 IBTP-tagged proteins can also be evaluated by immunoblotting using an antibody directed against the triphenylphosphonium moiety of the IBTP molecule.2 IBTP has also been used as a mitochondria-targeted soft electrophile to inhibit mitochondrial oxidative phosphorylation.3
Uses
IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols[1].
References
1. Lin, T.-K., Hughes, G., Muratovska, A., et al. Specific modification of mitochondrial protein thiols in response to oxidative stress: A proteomics approach J. Biol. Chem. 277(19),17048-17056(2002).
2. Venkatraman, A., Landar, A., Davis, A.J., et al. Oxidative modification of hepatic mitochondria protein thiols: Effect of chronic alcohol consumption Am. J. Physiol. Gastrointest. Liver Physiol. 286(4),G521-G527(2004).
3. Vayalil, P.K., Oh, J.-Y., Zhou, F., et al. A novel class of mitochondria-
IBTP ((4-Iodobutyl)triphenylphosphonium) Preparation Products And Raw materials
Raw materials
Preparation Products
IBTP ((4-Iodobutyl)triphenylphosphonium) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |