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ChemicalBook >> CAS DataBase List >>4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate

4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate

CAS No.
1577222-14-0
Chemical Name:
4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate
Synonyms
ALKS-8700;diroximel fumarate;Diroximel Fumarete;Diroximel Fumarete(ALKS-8700);Diroximel Fumarate DR Pellets;Diroximel fumarate, 10 mM in DMSO;5-dioxopyrrolidin-1-yl)ethyl methyl fumarate;2-(2,5-Dioxopyrrolidin-1-yl)ethyl methyl fumarate;2-(2,5-Dioxopyrrolidin-1-Yl)Ethyl Methyl Fumarate(WXC04774);2-(2,5-dioxopyrrolidin-1-yl)ethyl (E)-4-chloro-4-oxobut-2-enoate
CBNumber:
CB23070732
Molecular Formula:
C11H13NO6
Molecular Weight:
255.22
MDL Number:
MFCD28502263
MOL File:
1577222-14-0.mol
Last updated:2025-05-20 18:42:39

4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate Properties

Melting point 96 - 99°C
Boiling point 441.0±25.0 °C(Predicted)
Density 1.319±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Ethyl Acetate (Slightly)
form Solid
pka -1.60±0.20(Predicted)
color White to Off-White
FDA UNII K0N0Z40J3W

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29111 Diroximel Fumarate 1577222-14-0 5mg $81 2024-03-01 Buy
Cayman Chemical 29111 Diroximel Fumarate 1577222-14-0 50mg $553 2024-03-01 Buy
Cayman Chemical 29111 Diroximel Fumarate 1577222-14-0 10mg $143 2024-03-01 Buy
Cayman Chemical 29111 Diroximel Fumarate 1577222-14-0 25mg $336 2024-03-01 Buy
AK Scientific 6016DW Diroximelfumarate 1577222-14-0 50mg $714 2021-12-16 Buy
Product number Packaging Price Buy
29111 5mg $81 Buy
29111 50mg $553 Buy
29111 10mg $143 Buy
29111 25mg $336 Buy
6016DW 50mg $714 Buy

4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate Chemical Properties,Uses,Production

Description

Diroximel fumarate is a prodrug form of monomethyl fumarate . It undergoes esterase cleavage in the gut to release monomethyl fumarate. Formulations containing diroximel fumarate have been used in the treatment of relapsing-remitting multiple sclerosis.

Uses

Diroximel Fumarate is a novel oral fumarate in development for the treatment of patients with relapsing forms of multiple sclerosis.

in vivo

Diroximel fumarate (60-100 mg/kg , p.o., daily, 5 days) prevents MGO-induced mechanical and cold hypersensitivity in male and female wild-type C57BL/6 mice[2].

4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32284 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3148 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38668 58

View Lastest Price from 4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diroximel fumarate pictures 2025-05-20 Diroximel fumarate
1577222-14-0
 US $53.00-135.00 / mg 99.88% 10g TargetMol Chemicals Inc.
4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate pictures 2024-10-22 4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate
1577222-14-0
 US $1.00 / KG 1KG MIn98%HPLC/LC 100KGS Career Henan Chemica Co

1577222-14-0(4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate)Related Search:

(2E)-2-Butenedioic acid 1-[2-(2,5-dioxo-1-pyrrolidinyl)ethyl] 4-methyl ester 2-(2,5-Dioxopyrrolidin-1-yl)ethyl methyl fumarate 4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate ALKS-8700 diroximel fumarate DiroximelFumarete,ALKS-8700,4-O-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-O-methyl (E)-but-2-enedioate 2-Butenedioic acid (2E)-, 1-[2-(2,5-dioxo-1-pyrrolidinyl)ethyl] 4-methyl ester 5-dioxopyrrolidin-1-yl)ethyl methyl fumarate DIROXIMEL FUMARATE; ALKS8700; ALKS 8700; ALKS-8700;2-(2;5-DIOXOPYRROLIDIN-1-YL)ETHYL METHYL FUMARATE Diroximel Fumarete(ALKS-8700) (E)-but-2-enedioic acid 2-(2,5-dioxo-pyrrolidin-1-yl)ethyl ester methyl ester 2-(2,5-Dioxopyrrolidin-1-Yl)Ethyl Methyl Fumarate(WXC04774) Diroximel Fumarete Diroximel Fumarate DR Pellets Inhibitor,Diroximel,ALKS-8700,ALKS 8700,ALKS8700,BIIB 098,Diroximel fumarate,inhibit,BIIB098,BIIB-098 2-(2,5-dioxopyrrolidin-1-yl)ethyl (E)-4-chloro-4-oxobut-2-enoate Diroximel fumarate, 10 mM in DMSO 4-0-[2-(2,5-dioxopyrrolidin-1-yl)ethyl] 1-0-methyl (E)-but-2-enedioate 1577222-14-0 API