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ChemicalBook >> CAS DataBase List >>SR-9243

SR-9243

CAS No.
1613028-81-1
Chemical Name:
SR-9243
Synonyms
CS-1645;SR-9243;SR 9243;SR9243;SR-9243;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-;N-(3-Bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide;N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide;N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3’-(methylsulfonyl)[1,1’-biphenyl]-4-yl]methyl]-benzenesulfonamide;Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-
CBNumber:
CB23035285
Molecular Formula:
C31H32BrNO4S2
Molecular Weight:
626.62
MDL Number:
MFCD29049514
MOL File:
1613028-81-1.mol
Last updated:2024-11-19 23:02:33

SR-9243 Properties

Melting point 154-155°C
Boiling point 786.3±70.0 °C(Predicted)
Density 1.347±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in DMSO (greater than 25 mg/ml)
pka -6.90±0.70(Predicted)
form solid
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

HS Code  29350090

SR-9243 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18420 SR9243 ≥95% 1613028-81-1 1mg $32 2024-03-01 Buy
Cayman Chemical 18420 SR9243 ≥95% 1613028-81-1 5mg $70 2024-03-01 Buy
Cayman Chemical 18420 SR9243 ≥95% 1613028-81-1 10mg $109 2024-03-01 Buy
Cayman Chemical 18420 SR9243 ≥95% 1613028-81-1 50mg $351 2024-03-01 Buy
Tocris 6138 SR9243 ≥98%(HPLC) 1613028-81-1 10 $159 2021-12-16 Buy
Product number Packaging Price Buy
18420 1mg $32 Buy
18420 5mg $70 Buy
18420 10mg $109 Buy
18420 50mg $351 Buy
6138 10 $159 Buy

SR-9243 Chemical Properties,Uses,Production

Description

The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9243 is a cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations. It reduces cancer cell viability (IC50 values range from 15 to 104 nM) without cytotoxicity against non-malignant cells. SR9243 disrupts the Warburg effect in cancer cells, suppressing the expression of glycolytic and lipogenic genes and reducing glycolytic metabolites and lipid production. It is effective in vivo, blocking glycolytic and lipogenic gene expression and inducing apoptosis in colon cancer xenografts without inducing weight loss in mice.

Uses

SR9243 is used in new compounds targeting warburg effcts, killing cancer cells and inhibiting lipid production.

Definition

ChEBI: SR9243 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of mesitylene-2-sulphonic acid with the amino group of 2-(m-bromophenyl)ethylamine in which the nitrogen is substituted by a 4-[m-(methylsulfonyl)phenyl]benzyl group. It has a role as an antineoplastic agent, an apoptosis inducer and a liver X receptor inverse agonist. It is a sulfonamide, a sulfone and a member of bromobenzenes.

storage

Store at +4°C

References

1) Flaveny?et al. (2015),?Broad anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis; Cancer Cell,?28?42

SR-9243 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30238 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58

View Lastest Price from SR-9243 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SR9243 pictures 2024-11-19 SR9243
1613028-81-1
 US $32.00-72.00 / mg 99.03% 10g TargetMol Chemicals Inc.
  • SR9243 pictures
  • SR9243
    1613028-81-1
  • US $32.00-72.00 / mg
  • 99.03%
  • TargetMol Chemicals Inc.

SR-9243 Spectrum

SR-9243 N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]- CS-1645 SR 9243;SR9243;SR-9243 N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl- N-(3-Bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3’-(methylsulfonyl)[1,1’-biphenyl]-4-yl]methyl]-benzenesulfonamide 1613028-81-1 C31H32BrNO4S2 Inhibitors API