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ChemicalBook >> CAS DataBase List >>1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester

1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester

CAS No.
2765255-93-2
Chemical Name:
1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester
Synonyms
Ethyl 2-(3-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4H)-yl)acetate;1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester
CBNumber:
CB212682885
Molecular Formula:
C19H21F3N2O2
Molecular Weight:
366.38
MDL Number:
MOL File:
2765255-93-2.mol
Last updated:2025-05-17 18:20:32

1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Properties

Boiling point 462.2±45.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
form Solid
pka 1.52±0.20(Predicted)
color White to off-white

1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Chemical Properties,Uses,Production

Uses

JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia[1].

in vivo

JNJ-28583113 (10 mg/kg, 2?ml/kg; sc; single dose) is brain penetrant, and achieves 400?ng/mL in the brain compartment[1].

Animal Model:Harlan Sprague Dawley Rats (400 g)[1]
Dosage:10 mg/kg, 2?mL/kg
Administration:SC; sampled at 0.5, 2, or 6?h post dosing
Result:Quickly metabolized in the plasma, while it showed high levels in plasma and low levels in the brain.

IC 50

TRPM2

References

[1] Fourgeaud L, et al. Pharmacology of JNJ-28583113: A novel TRPM2 antagonist. Eur J Pharmacol. 2019 Jun 15;853:299-307. DOI:10.1016/j.ejphar.2019.03.043

1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9348 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4487 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62321 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139 orders@jknbiochem.com China 6179 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5519 58
Soochow Chirally Material Science and Technology Co.,Ltd 0512-66834346 17751187418 szkrl2022@126.com China 900 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20032 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705 qqyang@aikonchem.com China 10152 58

View Lastest Price from 1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JNJ-28583113 pictures 2025-05-17 JNJ-28583113
2765255-93-2
 US $87.00-312.00 / mg 98.57% 10g TargetMol Chemicals Inc.
  • JNJ-28583113 pictures
  • JNJ-28583113
    2765255-93-2
  • US $87.00-312.00 / mg
  • 98.57%
  • TargetMol Chemicals Inc.
1(4H)-Cycloheptapyrazoleacetic acid, 5,6,7,8-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, ethyl ester Ethyl 2-(3-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4H)-yl)acetate 2765255-93-2