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ChemicalBook >> CAS DataBase List >>2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-

2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-

CAS No.
433234-16-3
Chemical Name:
2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-
Synonyms
SMI-6860766;TRAFSTOP6860766;TRAFSTOP 6860766;TRAF-STOP 6860766;(E)-3-(4-bromo-2-chloroanilino)-1-phenylprop-2-en-1-one;2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-
CBNumber:
CB18665509
Molecular Formula:
C15H11BrClNO
Molecular Weight:
336.61
MDL Number:
MOL File:
433234-16-3.mol
Last updated:2025-04-18 09:51:44

2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Properties

Boiling point 417.5±45.0 °C(Predicted)
Density 1.509±0.06 g/cm3(Predicted)
pka -1.69±0.70(Predicted)

2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Chemical Properties,Uses,Production

Description

SMI-6860766 is a blocker of CD40-Traf6 interactions. It acts by ameliorating the complications of diet induced obesity in mice.

Uses

SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation[1].

in vivo

SMI 6860766 increases the number of adipocytes per field of view by 15.3% in mouse EpAT, indicating that SMI reduces adipocyte size, indicating reduces lipid storage and improves metabolic function[1].
SMI 6860766 reduces the number of total leukocytes (CD45+ cells) in mouse EpAT by 68.5%[1].
SMI 6860766 does not induce differences in hepatosteatosis[1].

References

[1] Van den Berg SM, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 May;39(5):782-90. DOI:10.1038/ijo.2014.198

2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 32292 58
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 19904 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai Chaolan Chemical Technology Center 021-QQ:65489617 15618227136 Sales@ATKchemical.com China 9347 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 4813 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24899 58
Shaoguan Qicheng Biotechnology Co., Ltd 18122215013 780229652@qq.com China 1265 58
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 6838 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 6051 58

View Lastest Price from 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SMI-6860766 pictures 2024-10-24 SMI-6860766
433234-16-3
US $1980.00-2500.00 / mg 10g TargetMol Chemicals Inc.
  • SMI-6860766 pictures
  • SMI-6860766
    433234-16-3
  • US $1980.00-2500.00 / mg
  • TargetMol Chemicals Inc.
2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- SMI-6860766 TRAFSTOP 6860766 TRAF-STOP 6860766 TRAFSTOP6860766 (E)-3-(4-bromo-2-chloroanilino)-1-phenylprop-2-en-1-one 433234-16-3