2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-
- CAS No.
- 433234-16-3
- Chemical Name:
- 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-
- Synonyms
- SMI-6860766;TRAFSTOP6860766;TRAFSTOP 6860766;TRAF-STOP 6860766;(E)-3-(4-bromo-2-chloroanilino)-1-phenylprop-2-en-1-one;2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-
- CBNumber:
- CB18665509
- Molecular Formula:
- C15H11BrClNO
- Molecular Weight:
- 336.61
- MDL Number:
- MOL File:
- 433234-16-3.mol
2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Chemical Properties,Uses,Production
Description
SMI-6860766 is a blocker of CD40-Traf6 interactions. It acts by ameliorating the complications of diet induced obesity in mice.
Uses
SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation[1].
in vivo
SMI 6860766 increases the number of adipocytes per field of view by 15.3% in mouse EpAT, indicating that SMI reduces adipocyte size, indicating reduces lipid storage and improves metabolic function[1].
SMI 6860766 reduces the number of total leukocytes (CD45+ cells) in mouse EpAT by 68.5%[1].
SMI 6860766 does not induce differences in hepatosteatosis[1].
References
[1] Van den Berg SM, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 May;39(5):782-90. DOI:10.1038/ijo.2014.198
2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Preparation Products And Raw materials
Raw materials
Preparation Products
2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32292 | 58 |
TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19904 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
Shanghai Chaolan Chemical Technology Center | 021-QQ:65489617 15618227136 | Sales@ATKchemical.com | China | 9347 | 58 |
Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4813 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24899 | 58 |
Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 1265 | 58 |
Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
View Lastest Price from 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-10-24 | SMI-6860766
433234-16-3
|
US $1980.00-2500.00 / mg | 10g | TargetMol Chemicals Inc. |
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- SMI-6860766
433234-16-3
- US $1980.00-2500.00 / mg
- TargetMol Chemicals Inc.