PHRIXOTOXIN 3
- CAS No.
- 880886-00-0
- Chemical Name:
- PHRIXOTOXIN 3
- Synonyms
- PHRIXOTOXIN 3
- CBNumber:
- CB14724231
- Molecular Formula:
- C176H269N51O48S6
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
PHRIXOTOXIN 3 price More Price(3)
PHRIXOTOXIN 3 Chemical Properties,Uses,Production
Description
Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV2, NaV3 and NaV5 respectively). Blocks inward sodium currents in a voltage-dependent manner.
Uses
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current[1].
IC 50
Nav1.3: 42 nM (IC50); Nav1.4: 72 nM (IC50); Nav1.5: 610 nM (IC50); Nav1.2: 0.6 nM (IC50); Nav1.1: 288 nM (IC50)
storage
Store at -20°C
References
[1] Bosmans F, et, al. Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Comparative Study Mol Pharmacol. 2006 Feb; 69(2): 419-29. DOI:10.1124/mol.105.015941
PHRIXOTOXIN 3 Preparation Products And Raw materials
Raw materials
Preparation Products
PHRIXOTOXIN 3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5221 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | Caroline@youngshechem.com | China | 4803 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7061 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Hangzhou Go Top Peptide Biotech | 15397062932 | sales1@gotopbio.com | China | 2884 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
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