RORγt inhibitor 1
- CAS No.
- 2079892-79-6
- Chemical Name:
- RORγt inhibitor 1
- Synonyms
- RORγt inhibitor 1;RORγt Inverse agonist 8;(S)-N-(8-((4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl)methyl)-7-methylimidazo[1,2-a]pyridin-6-yl)-2-methylpyrimidine-5-carboxamide;N-[8-[[(3S)-4-(Cyclopentylcarbonyl)-3-methyl-1-piperazinyl]methyl]-7-methylimidazo[1,2-a]pyridin-6-yl]-2-methyl-5-pyrimidinecarboxam ide;5-Pyrimidinecarboxamide, N-[8-[[(3S)-4-(cyclopentylcarbonyl)-3-methyl-1-piperazinyl]methyl]-7-methylimidazo[1,2-a]pyridin-6-yl]-2-methyl-
- CBNumber:
- CB14668454
- Molecular Formula:
- C26H33N7O2
- Molecular Weight:
- 475.59
- MDL Number:
- MFCD34469367
- MOL File:
- 2079892-79-6.mol
RORγt inhibitor 1 Chemical Properties,Uses,Production
Description
GKN92796, also known as RORγt inhibitor 1, is a RORγt inhibitor. This product has no formal name at the moment.
Uses
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist, with an IC50 of 19 nM for human RORγt-LBD[1].
in vivo
RORγt Inverse agonist 8 (15 mg/kg, 45 mg/kg ; i.g.; twice daily; for 7 days) ameliorates antigen-induced arthritis (AiA) responses in Lewis rats[1].
| Animal Model: | Female Lewis rats (190–220 g)[1] |
| Dosage: | 15 mg/kg, 45 mg/kg |
| Administration: | Oral gavage; twice daily; for 7 days |
| Result: | Ameliorates antigen-induced arthritis (AiA) responses in Lewis rats. |
References
[1] Guendisch U, et al. Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo. PLoS One. 2017 Nov 20;12(11):e0188391. DOI:10.1371/journal.pone.0188391
RORγt inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
RORγt inhibitor 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19903 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29772 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20622 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
View Lastest Price from RORγt inhibitor 1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | RORγt Inverse agonist 8
2079892-79-6
|
US $1670.00-2800.00 / mg | 10g | TargetMol Chemicals Inc. |
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- RORγt Inverse agonist 8
2079892-79-6
- US $1670.00-2800.00 / mg
- TargetMol Chemicals Inc.