ChemicalBook >> CAS DataBase List >>N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
![N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Structure](CAS/20180527/GIF/827001-82-1.gif)
- CAS No.
- 827001-82-1
- Chemical Name:
- N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
- Synonyms
- 5J 4;5J-4, 10 mM in DMSO;Orai1/CRAC Blocker, Cpd5J-4;N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide;N-((6-Hydroxynaphthalen-1-yl)carbamothioyl)furan-2-carboxamide;2-Furancarboxamide, N-[[(6-hydroxy-1-naphthalenyl)amino]thioxomethyl]-;Inhibitor,Calcium release-activated channels,CRAC Channel,CNS,Ca2+ release-activated Ca2+ channels,5J 4,inflammation,5J4,inhibit,CD4+ cells,mononuclear cell,experimental autoimmune encephalomyelitis,5J-4
- CBNumber:
- CB13373021
- Molecular Formula:
- C16H12N2O3S
- Molecular Weight:
- 312.34
- MDL Number:
- MFCD05832424
- MOL File:
- 827001-82-1.mol
Last updated:2025-04-28 21:36:36
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Chemical Properties,Uses,Production
Uses
N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide inhibits or blocks the calcium release-activated calcium (CRAC) channel for alleviation of autoimmune diseases.
Biological Activity
Primary Target
Orail1
in vivo
5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt[1].
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].
| Animal Model: | C57BL/6 mice (MOG35-55 peptide-immunized mice)[1] |
| Dosage: | 2 m/kg |
| Administration: | I.p., every alternate day for 30 days |
| Result: | Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population. |
storage
Store at -20°C
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide Suppliers
Global( 17)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32276 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 848 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62321 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24884 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 4726 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| R&D Systems, Inc | 18003437475 18003437475 | rdname@qq.com | China | 35960 | 58 |
View Lastest Price from N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide manufacturers
N-[(6-Hydroxy-1-naphthyl)carbamothioyl]-2-furamide
2-Furancarboxamide, N-[[(6-hydroxy-1-naphthalenyl)amino]thioxomethyl]-
5J 4
Inhibitor,Calcium release-activated channels,CRAC Channel,CNS,Ca2+ release-activated Ca2+ channels,5J 4,inflammation,5J4,inhibit,CD4+ cells,mononuclear cell,experimental autoimmune encephalomyelitis,5J-4
5J-4, 10 mM in DMSO
Orai1/CRAC Blocker, Cpd5J-4
N-((6-Hydroxynaphthalen-1-yl)carbamothioyl)furan-2-carboxamide
827001-82-1