3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
![3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone Structure](CAS/20150408/GIF/342808-40-6.gif)
- CAS No.
- 342808-40-6
- Chemical Name:
- 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone
- Synonyms
- EF-24;EF24, 10 mM in DMSO;3,5-Bis(2-fluorobenzylidene)piperidin-4-one;5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone;3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone;4-Piperidinone, 3,5-bis[(2-fluorophenyl)methylene]-;(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone;ERK,EF24,Caspase,inhibit,Inhibitor,Extracellular signal regulated kinases
- CBNumber:
- CB12695159
- Molecular Formula:
- C19H15F2NO
- Molecular Weight:
- 311.33
- MDL Number:
- MFCD08560185
- MOL File:
- 342808-40-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H400-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50 |
| Safety Statements | 61 |
| WGK Germany | 3 |
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E8409 | EF-24 ≥98% (HPLC) | 342808-40-6 | 5mg | $106 | 2024-03-01 | Buy |
| Sigma-Aldrich | E8409 | EF-24 ≥98% (HPLC) | 342808-40-6 | 25mg | $419 | 2024-03-01 | Buy |
| TRC | B434770 | 3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone | 342808-40-6 | 2.5g | $1650 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0151819 | (3E,5E)-3,5-BIS[(2-FLUOROPHENYL)METHYLENE]-4-PIPERIDINONE 95.00% | 342808-40-6 | 10MG | $1963.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0151819 | (3E,5E)-3,5-BIS[(2-FLUOROPHENYL)METHYLENE]-4-PIPERIDINONE 95.00% | 342808-40-6 | 1MG | $750.75 | 2021-12-16 | Buy |
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone Chemical Properties,Uses,Production
Uses
3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone is an analog of curcumin that acts as a kinase inhibitor which mediates anticancer properties.
Biological Activity
EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcumin, with 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1alpha posttranscriptional activity and induces microtubule stabilization, in contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IkappaB kinase (IKK), resulting in suppression in NFKB activity.', 'EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcumin, with 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1α posttranscriptional activity and induces microtubule stabilization, in contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IK B kinase (IKK), resulting in suppression in NFKB activity. EF-24/(3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone is a curcuminoid, th at helps to decrease cisplatin-mediated reactive oxygen species in zebrafish. It is highly bioavailable than curcumin and has the ability to target cancer.
in vivo
EF24 (0.4 mg/kg, i.p., a single dose for 6 h) markedly ameliorates the post-hemorrhage morphologic changes and inflammatory cell infiltration, inhibits hemorrhage-induced NF-kB phosphorylation in rat model of hemorrhage[4].
| Animal Model: | Rat model of hemorrhage[4] |
| Dosage: | 0.4 mg/kg |
| Administration: | i.p., a single dose for 6 h |
| Result: | Prevented the hemorrhage-induced increase in myeloperoxidase activity and phospho-NF-kB p65 in hemorrhaged lung tissue. |
3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21626 | 55 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9297 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6443 | 55 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2984 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10123 | 58 |