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ChemicalBook >> CAS DataBase List >>(±)14(15)-EET-SI

(±)14(15)-EET-SI

CAS No.
218461-97-3
Chemical Name:
(±)14(15)-EET-SI
Synonyms
(±)14(15)-EET-SI;(±)14(15)-EET-SI;5,8,11-Tridecatrienamide, N-(methylsulfonyl)-13-(3-pentyl-2-oxiranyl)-, (5Z,8Z,11Z)-
CBNumber:
CB12589791
Molecular Formula:
C21H35NO4S
Molecular Weight:
397.57
MDL Number:
MFCD12912332
MOL File:
218461-97-3.mol
Last updated:2025-04-17 18:22:24

(±)14(15)-EET-SI Properties

Density 1.060±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
pka 4.63±0.40(Predicted)

SAFETY

Risk and Safety Statements

(±)14(15)-EET-SI price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009286 (±)14(15)-EET-SI ≥95% 218461-97-3 25μg $81 2024-03-01 Buy
Cayman Chemical 10009286 (±)14(15)-EET-SI ≥95% 218461-97-3 50μg $152 2024-03-01 Buy
Cayman Chemical 10009286 (±)14(15)-EET-SI ≥95% 218461-97-3 100μg $286 2024-03-01 Buy
American Custom Chemicals Corporation LIP0000668 N-(METHYLSULFONYL)-13-(3-PENTYLOXIRANYL)-5Z,8Z,11Z-TRIDECATRIENAMIDE 95.00% 218461-97-3 5MG $496.39 2021-12-16 Buy
Product number Packaging Price Buy
10009286 25μg $81 Buy
10009286 50μg $152 Buy
10009286 100μg $286 Buy
LIP0000668 5MG $496.39 Buy

(±)14(15)-EET-SI Chemical Properties,Uses,Production

Description

Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch.1 (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries.1 In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.2

Uses

14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA[1].

References

1. Gauthier, K.M., Falck, J.R., Reddy, L.M., et al. 14,15-EET analogs: Characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries Pharmacol. Res. 49(6),515-524(2004).
2. Chen, J.K., Falck, J.R., Reddy, K.M., et al. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells J. Biol. Chem. 273(44),29254-29261(1998).

(±)14(15)-EET-SI Preparation Products And Raw materials

Raw materials

Preparation Products

(±)14(15)-EET-SI Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+17819995354 marketing@targetmol.com United States 32286 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24898 58
Hubei Danding Pharmaceutical Technology Co., Ltd 17701422016 17701422016 3587493084@qq.com China 8892 58
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 6838 58
Santa Cruz Biotechnology Inc 021-60936350 scbt@scbt.com China 6594 58

View Lastest Price from (±)14(15)-EET-SI manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(±)14(15)-EET-SI pictures 2024-10-24 (±)14(15)-EET-SI
218461-97-3
US $380.00 / μg 10g TargetMol Chemicals Inc.
(±)14(15)-EET-SI 5,8,11-Tridecatrienamide, N-(methylsulfonyl)-13-(3-pentyl-2-oxiranyl)-, (5Z,8Z,11Z)- (±)14(15)-EET-SI 218461-97-3