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ChemicalBook >> CAS DataBase List >>QX 314 chloride

QX 314 chloride

CAS No.
5369-03-9
Chemical Name:
QX 314 chloride
Synonyms
QX314.Cl;QX 314 CHLORIDE;N-Ethyllidocaine chloride;Lidocaine N-ethyl chloride;QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride
CBNumber:
CB1191994
Molecular Formula:
C16H27ClN2O
Molecular Weight:
298.85
MDL Number:
MFCD01669894
MOL File:
5369-03-9.mol
Last updated:2024-11-20 11:41:24

QX 314 chloride Properties

Melting point 209-211 °C
storage temp. Room temp
solubility insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O
form solid
color White
Water Solubility Soluble in water (100mM)

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

QX 314 chloride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L1663 Lidocaine N-ethyl chloride 5369-03-9 500MG $315 2023-06-20 Buy
Sigma-Aldrich L1663 Lidocaine N-ethyl chloride 5369-03-9 1G $579 2023-06-20 Buy
Cayman Chemical 18454 QX-314 (chloride) ≥98% 5369-03-9 50mg $121 2024-03-01 Buy
Tocris 2313 QX314chloride ≥99%(HPLC) 5369-03-9 50 $139 2021-12-16 Buy
TRC Q950010 QX314Chloride 5369-03-9 50mg $130 2021-12-16 Buy
Product number Packaging Price Buy
L1663 500MG $315 Buy
L1663 1G $579 Buy
18454 50mg $121 Buy
2313 50 $139 Buy
Q950010 50mg $130 Buy

QX 314 chloride Chemical Properties,Uses,Production

Uses

QX 314 Chloride has been shown to have antitussive properties in mammalian animal models.

Uses

QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.

Biochem/physiol Actions

Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

storage

Room temperature

QX 314 chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22784 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Shanghai Universal Biotech Co.,Ltd 13774214275 zhouzz@univ-bio.com China 24994 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216 info@yuhaochemical.com China 9387 52

View Lastest Price from QX 314 chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
QX-314 chloride pictures 2024-11-19 QX-314 chloride
5369-03-9
 US $132.00-48.00 / mg 99.73% 10g TargetMol Chemicals Inc.
QX-314 chloride pictures 2024-11-19 QX-314 chloride
5369-03-9
 US $132.00-48.00 / mg 99.73% 10g TargetMol Chemicals Inc.
QX 314 chloride pictures 2022-05-13 QX 314 chloride
5369-03-9
 US $1.10 / g 1g 99.0% Min 100 Tons Dideu Industries Group Limited
  • QX-314 chloride pictures
  • QX-314 chloride
    5369-03-9
  • US $132.00-48.00 / mg
  • 99.73%
  • TargetMol Chemicals Inc.
  • QX-314 chloride pictures
  • QX-314 chloride
    5369-03-9
  • US $132.00-48.00 / mg
  • 99.73%
  • TargetMol Chemicals Inc.
  • QX 314 chloride pictures
  • QX 314 chloride
    5369-03-9
  • US $1.10 / g
  • 99.0% Min
  • Dideu Industries Group Limited
QX 314 CHLORIDE N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE QX314.Cl 2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride [2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride [2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride Lidocaine N-ethyl chloride N-Ethyllidocaine chloride QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE Inhibitor,calcium,Sodium Channel,QX314 chloride,channel,Na channels,QX314,sodium,Na+ channels,QX-314,inhibit,QX 314 chloride,QX 314 5369-03-9 5369-3-9 C16H27N2OCl Cell Signaling and Neuroscience Cell Biology BioChemical Other Sodium Channel Modulators Monovalent Ion Channels Ion Channels Voltage-gated Ion Channels Sodium Channel Modulators Ion Channels