AMX12006
- CAS No.
- 2639775-01-0
- Chemical Name:
- AMX12006
- Synonyms
- AMX12006;Benzoic acid, 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]-
- CBNumber:
- CB114133663
- Molecular Formula:
- C26H22F3N3O3
- Molecular Weight:
- 481.47
- MDL Number:
- MOL File:
- 2639775-01-0.mol
AMX12006 Chemical Properties,Uses,Production
Uses
AMX12006 is a potent, selective and orally active EP4 antagonist with an IC50 value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity[1].
in vivo
AMX12006 (75, 150 mg/kg; p.o.; once daily for 11 days) shows antitumor activity in a dose-dependent manner[1].
Pharmacokinetic Parameters of AMX12006 in Sprague-Dawley rats[1].
| iv, 1 mg/kg | po, 10 mg/kg | |
| Tmax (h) | 0.5 | |
| Cmax (ng/mL) | 4627 ± 304 | 8243 ± 370 |
| AUC(0-t)(h·ng/mL) | 3375 ± 477 | 25672 ± 5668 |
| AUC0–∞ (h·ng/mL) | 3416 ± 495 | 25707 ± 5682 |
| T1/2(h) | 1.4 ± 0.3 | 2.7 ± 0.2 |
| CL (mL/min/kg) | 4.95 ± 0.77 | |
| Vdss (L/kg) | 0.41 ± 0.04 | |
| F % | 76.1 |
IC 50
hEP4: 4.3 nM (IC50)
References
[1] Debasis Das, et al. Discovery of Novel, Selective Prostaglandin EP4 Receptor Antagonists with Efficacy in Cancer Models. ACS Med. Chem. Lett. 2023.
AMX12006 Preparation Products And Raw materials
Raw materials
Preparation Products
AMX12006 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20032 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 27736 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Cayman Chemical Company | 58 |