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ChemicalBook >> CAS DataBase List >>(Rac)-BRD0705

(Rac)-BRD0705

CAS No.
1597440-03-3
Chemical Name:
(Rac)-BRD0705
Synonyms
(Rac)-BRD0705;(Rac)-BRD0705, 10 mM in DMSO;5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-;GSK3α,inhibit,Racemate,(Rac)BRD0705,GSK-3,Inhibitor,Glycogen synthase kinase-3,(Rac) BRD0705,(Rac)-BRD-0705,Glycogen synthase kinase 3,(Rac)-BRD0705
CBNumber:
CB08054513
Molecular Formula:
C20H23N3O
Molecular Weight:
321.42
MDL Number:
MOL File:
1597440-03-3.mol
Last updated:2025-04-18 09:51:30

(Rac)-BRD0705 Properties

Boiling point 512.0±50.0 °C(Predicted)
Density 1.22±0.1 g/cm3(Predicted)
pka 14.82±0.60(Predicted)
form Solid
color Light yellow to yellow

(Rac)-BRD0705 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Axon Medchem Axon3154 rac-BRD0705 99% 1597440-03-3 5mg $154 2021-12-16 Buy
Product number Packaging Price Buy
Axon3154 5mg $154 Buy

(Rac)-BRD0705 Chemical Properties,Uses,Production

Uses

(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].

References

[1] Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. DOI:10.1126/scitranslmed.aam8460
[2] Edward Scolnick, et al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1.

(Rac)-BRD0705 Preparation Products And Raw materials

Raw materials

Preparation Products

(Rac)-BRD0705 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32239 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38648 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Wuhan chuang he chemical co. LTD 15907120073 1261789306@qq.com China 1186 58
Hefei fuya biotechnology co. LTD 18096409024 sales02@foreversyn.com China 1951 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24739 58
guoyungurui 18162595016; 18162595016 3287908757@qq.com China 10335 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
4008-099-669 23419001name@qq.com CHINA 73043 58

View Lastest Price from (Rac)-BRD0705 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(Rac)-BRD0705 pictures 2024-11-19 (Rac)-BRD0705
1597440-03-3
 US $88.00-333.00 / mg 99.67% 10g TargetMol Chemicals Inc.
(Rac)-BRD0705 pictures 2024-11-19 (Rac)-BRD0705
1597440-03-3
 US $88.00-333.00 / mg 99.67% 10g TargetMol Chemicals Inc.
  • (Rac)-BRD0705 pictures
  • (Rac)-BRD0705
    1597440-03-3
  • US $88.00-333.00 / mg
  • 99.67%
  • TargetMol Chemicals Inc.
  • (Rac)-BRD0705 pictures
  • (Rac)-BRD0705
    1597440-03-3
  • US $88.00-333.00 / mg
  • 99.67%
  • TargetMol Chemicals Inc.

(Rac)-BRD0705 Spectrum

(Rac)-BRD0705 GSK3α,inhibit,Racemate,(Rac)BRD0705,GSK-3,Inhibitor,Glycogen synthase kinase-3,(Rac) BRD0705,(Rac)-BRD-0705,Glycogen synthase kinase 3,(Rac)-BRD0705 5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl- (Rac)-BRD0705, 10 mM in DMSO 1597440-03-3