AGI-24512
- CAS No.
- 2201066-53-5
- Chemical Name:
- AGI-24512
- Synonyms
- AGI-24512;6-(4-Hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one;Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(1-piperidinyl)-;Inhibitor,inhibit,DNA damage response,anticancer,methylthioadenosine phosphorylase,AGI 24512,Methionine Adenosyltransferase (MAT),PRMT5,AGI24512,AGI-24512,antiproliferative,MTAP,HCT116,S-adenosylmethionine Synthetase,MAT2A
- CBNumber:
- CB04672630
- Molecular Formula:
- C24H24N4O2
- Molecular Weight:
- 400.47
- MDL Number:
- MOL File:
- 2201066-53-5.mol
AGI-24512 Chemical Properties,Uses,Production
Description
AGI-24512 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-24512 showed in vivo activity in MTAP null tumors.
Uses
AGI-24512 is a potent methionine adenosyltransferase 2α (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer[1].
in vivo
AGI-24512 shows poor oral absorption and a short half-life in rats[2].
References
[1] Kalev P, et al. MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage. Cancer Cell. 2021 Feb 8;39(2):209-224.e11. DOI:10.1016/j.ccell.2020.12.010
[2] Konteatis Z, et al. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J Med Chem. 2021 Apr 22;64(8):4430-4449. DOI:10.1021/acs.jmedchem.0c01895
AGI-24512 Preparation Products And Raw materials
Raw materials
Preparation Products
AGI-24512 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32276 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 42446 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| AgileBioChem Co., Ltd. | 18055517827 | sales@agilebiochem.com | China | 1002 | 50 |
| Shanghai Akasaka Biotechnology Co., Ltd. | 15121162054 | CHINA | 635 | 58 | |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |