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ChemicalBook >> CAS DataBase List >>Vitamin A palmitate

Vitamin A palmitate

CAS No.
79-81-2
Chemical Name:
Vitamin A palmitate
Synonyms
RETINYL PALMITATE;RETINOL PALMITATE;Vitamin a Palmitate Oil;Vitamin A Palmitate Powder;VitaminAPalmitateinOil;Dry Vitamin A Palmitate;Retinylpalmitat;VITAMINE A PALMITATE;VITAMIN A PALMITATE Liquid;VITAMIN A PALMITATE 1.7 MIU
CBNumber:
CB0406543
Molecular Formula:
C36H60O2
Molecular Weight:
524.86
MDL Number:
MFCD00019414
MOL File:
79-81-2.mol
Last updated:2024-12-18 13:37:16

Vitamin A palmitate Properties

Melting point 28-29℃
Boiling point 546.51°C (rough estimate)
Density 0.9668 (rough estimate)
refractive index 1.5250 (estimate)
Flash point 194℃
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
form oil
color Light Yellow to Yellow
Specific Gravity 0.90～0.93 (20℃)
Water Solubility Soluble in chloroform, ether, and vegetable oils. Insoluble in water.
Merck 13,10073
BRN 1917366
BCS Class 4
Stability Light Sensitive
InChIKey VYGQUTWHTHXGQB-YFAKFODJSA-N
LogP 15.51 at 25℃
CAS DataBase Reference 79-81-2(CAS DataBase Reference)
FDA 21 CFR 582.5936; 310.545
Substances Added to Food (formerly EAFUS) VITAMIN A PALMITATE
SCOGS (Select Committee on GRAS Substances) Vitamin A palmitate
NCI Dictionary of Cancer Terms retinyl palmitate
FDA UNII 1D1K0N0VVC
NIST Chemistry Reference Vitamin a palmitate(79-81-2)
EPA Substance Registry System Retinol, hexadecanoate (79-81-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360D-H412
Precautionary statements  P202-P273-P280-P308+P313-P405-P501
Hazard Codes  T,Xn,F
Risk Statements  63-53-61-11
Safety Statements  53-23-36/37/39-45-36/37-16-60
RIDADR  UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany  3
RTECS  VH6860000
F  8-10-23
TSCA  Yes
HS Code  29362100
Toxicity LD50 (10 day) in mice, rats (mg/kg): 6060, 7910 orally (Kamm)

Vitamin A palmitate price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 46959-U Retinol palmitate analytical standard 79-81-2 100mg $35.7 2024-03-01 Buy
Sigma-Aldrich 1602502 Retinyl palmitate United States Pharmacopeia (USP) Reference Standard 79-81-2 4x50mg $447 2024-03-01 Buy
Alfa Aesar J63022 Vitamin A palmitate, 1.7 M.I.U./g 79-81-2 25g $73.8 2024-03-01 Buy
Alfa Aesar J63022 Vitamin A palmitate, 1.7 M.I.U./g 79-81-2 100g $225 2024-03-01 Buy
Cayman Chemical 23796 Retinyl Palmitate ≥95% 79-81-2 5g $62 2024-03-01 Buy
Product number Packaging Price Buy
46959-U 100mg $35.7 Buy
1602502 4x50mg $447 Buy
J63022 25g $73.8 Buy
J63022 100g $225 Buy
23796 5g $62 Buy

Vitamin A palmitate Chemical Properties,Uses,Production

Chemical Properties

95.0-100.5% Absorbance @325 nm ≥0.85%

Uses

antihypertensive

Uses

vitamin A palmitate is known as a skin “normalizer.” It acts as an antikeratinizing agent, helping the skin stay soft and plump, and improving its water-barrier properties. Because of its impact on the skin’s water-barrier properties, it is useful against dryness, heat, and pollution. It is also an anti-oxidant and is suggested for use in sunscreens. Clinical studies with vitamin A palmitate indicate a significant change in skin composition, with increases in collagen, DnA, skin thickness, and elasticity. Vitamin A palmitate’s stability is superior to retinol.

Uses

all-trans-Retinyl Palmitate is an ester derivative of Retinol (R252000). all-trans-Retinyl Palmitate is used as a vitamin supplement in the treatment of Vitamin A deficiency. all-trans-Retinyl Palmita te is used as an antioxidant and a source of vitamin A added to low fat milk and other dairy products. all-trans-Retinyl Palmitate is also a constituent of some topically applied skin care products

Uses

retinyl palmitate is a skin conditioner. This retinoid is considered a milder version of retinoic acid, given its conversion properties. once on the skin, it converts to retinol, which in turn converts to retinoic acid. Physiologically, it is credited with increasing R epidermal thickness, stimulating the production of more epidermal protein, and increasing skin elasticity. Cosmetically, retinyl palmitate is used to reduce the number and depth of fine lines and wrinkles, and prevent skin roughness resulting from uV exposure. Secondary reactions such as erythema, dryness, or irritation are not associated with retinyl palmitate. It is even more effective when used in combination with glycolic acid because it achieves greater penetration. In the united States, its maximum usage level in cosmetic formulations is 2 percent. Retinyl palmitate is the ester of retinol and palmitic acid.

Definition

ChEBI: All-trans-retinyl palmitate is an all-trans-retinyl ester obtained by formal condensation of the carboxy group of palmitic (hexadecanoic acid) with the hydroxy group of all-trans-retinol. It is used in cosmetic products to treat various skin disorders such as acne, skin aging, wrinkles, dark spots, and also protect against psoriasis. It has a role as an Escherichia coli metabolite, a human xenobiotic metabolite and an antioxidant. It is a retinyl palmitate and an all-trans-retinyl ester. It is functionally related to an all-trans-retinol.

General Description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Retinyl palmitate belongs to a category of compounds called retinoids, which are chemically similar to vitamin A. It exhibits a beneficial effect on vision, skin and immune function, inhibits cell proliferation and prevents cancer. It is an important dietary as well as a therapeutic compound.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Vitamin A palmitate is widely used in pharmaceutical applications. It is also extensively used in cosmetic formulations due to its beneficial effects on the appearance of skin and anti-oxidant properties. Vitamin A palmitate acts as a teratogen and affect vertebrate embryogenesis and regeneration. It is added as a source of vitamin A in low fat and skim milks. Vitamin A palmitate acts as a chemopreventive or antineoplastic agent.
Review: Vitamin A metabolism.

Side effects

Vitamin A palmitate is fat-soluble and is stored in the body's fatty tissue. Therefore, excessive levels of vitamin A palmitate can lead to toxicity and liver disease. This is more likely to occur when taking supplements than when consuming them from food. People with liver disease should not take vitamin A palmitate supplements. Excessive doses of vitamin A supplements have been linked to birth defects, including malformations of the eyes, lungs, skull and heart. They are not recommended for pregnant women. Regular high doses of vitamin A letter source can lead to depression, dry skin, and muscle and joint pain.

Safety Profile

Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

The palmitate is separated from retinol by column chromatography on water-deactivated alumina with hexane containing a very small percentage of acetone. It is also chromatographed on TLC silica gel G, using pet ether/isopropyl ether/acetic acid/water (180:20:2:5) or pet ether/acetonitrile/acetic acid/water (190:10:1:15) to develop the chromatogram. It is then recrystallised from propylene at low temperature (below -47o). [Beilstein 6 IV 4135.]

Vitamin A palmitate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 445)Suppliers
Supplier Tel Email Country ProdList Advantage
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD
15202951039 jason@sgonekbio.com China 268 58
Hebei Saisier Technology Co., LTD
+86-18400010335 +86-18034520335 admin@hbsaisier.cn China 1015 58
Aurora Industry Co., Ltd.
+86-13591747876 +86-13591747876 alex1_auco@126.com China 277 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Hebei Yime New Material Technology Co., Ltd. 		+86-66697723 +86-17703311139 admin@china-yime.com China 563 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5889 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-17333973358 sales06@hbduling.cn China 8051 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Hebei Kingfiner Technology Development Co.Ltd 		+86-15532196582 +86-15373005021 lisa@kingfinertech.com China 3010 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1001 58

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View Lastest Price from Vitamin A palmitate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vitamin A palmitate pictures 2024-12-20 Vitamin A palmitate
79-81-2
 US $6.00 / kg 1kg 99% 2000KG/Month HebeiShuoshengImportandExportco.,Ltd
Vitamin A palmitate pictures 2024-12-20 Vitamin A palmitate
79-81-2
 US $10.00 / kg 1kg 99% 5000kg/Week Hebei Zhuanglai Chemical Trading Co.,Ltd
Vitamin A palmitate pictures 2024-12-19 Vitamin A palmitate
79-81-2
 US $6.00 / kg 1kg More than 99% 2000KG/Month Hebei Longbang Technology Co., Ltd
VITAMINAPALMITATE,LIQUIDINOIL,1MILLIONIU/G VITAMINAPALMITATE,USP [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenyl] hexadecanoate VITAMIN A PALMITATE(RETINYL PALMITATE)(RG) ALL-TRANS-RETINYLPALMITATE VITAMIN-A-PALMITATE, STAB., 1750 U/MG VITAMIN A PALMITATE LIQUID WITH TOCOPHERYL all-trans-Retinol palmitate, VitaminA palmitate C02588 Vitamin A palmitate 1g [79-81-2] Vitamin A - oily and dry forms VitaMin-A-PalMitate 1.7 (2E,4E,6E,8E)-3,7-diMethyl-9-(2,6,6-triMethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl palMitate VitaMin A palMitate, 1,700,000 units/g Retinyl (Vitamin A) Palmitate Retinyl palmitate solution Retinyl Palmitate (4 x 50 mg) retinol palmitate type iv sigma grade RETINOL PALMITATE, 100MG, NEAT RETINOL PALMITATE TYPE VI VITAMIN A PALMITATE 1.7 MILLION IU/G VITAMIN A PALMITATE 250000 U.S.P UNITS GM VITAMIN A PALMITATE SYNTHETIC 1MILLION UNITS GM VitaminAPalmitateB.P.,U.S.P. vitamine Cpalmitate RETINYL PALMITATE TYPE IV, ACTIVITY: Retinyl Palmitate (Vitamin A Palmitate) AROVIT ALL TRANS-RETINOL PALMITATE RETINOL PALMITATE ALL TRANS RETINOL PALMITATE ALL TRANS ISOMER RETINOL PALMITATE TYPE IV: ALL TRANS VITAMIN A PALMITATE 3,7-Dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol palmitate all-trans-retinopalmitate Ester found in fish liver oils Optovit-A Retinol, hexadecanoate Retinol,hexadecanate retinol,hexadecanoate Nanoactive A BioaActive Vitamin A BioActive VA NanoActive VA Nanoactive Vitamin A Soluble Vitamin A Retinyl palmitat (vitamin A palmitate) skype : honestcooperation Nano Liposomal Vitamin A, Nanoactive Vitamin A, Vitamin A NanoEmulsion, BioActive VA, NanoActive VA, Soluble Vitamin A NanoLiposomal Retinyl palmitate Retinyl palmitate (Synonyms: Vitamin A palmitate Retinol Pro Retinol palmitate, ≥1700000 USP units /g hexadecanoic acid [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenyl] ester Vitamin A palmitate (~1,800,000 IU/g) Vitamin A palmitate Solution Inhibited with BHT Retinol Palmitate RS Retinol Palmitate Standard Solution Vitamin A Impurity 7