(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- CAS No.
- 1215197-37-7
- Chemical Name:
- (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
- Synonyms
- PF-04991532;PF 04991532;PF 04991532,PF04991532;PF-04991532 >=98% (HPLC);(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid;6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 6-[[(2S)-3-cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-
- CBNumber:
- CB02657114
- Molecular Formula:
- C18H19F3N4O3
- Molecular Weight:
- 396.36
- MDL Number:
- MFCD27938256
- MOL File:
- 1215197-37-7.mol
| Boiling point | 646.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 3.55±0.10(Predicted) |
| form | powder |
| color | white to beige |
| FDA UNII | AJ212MS2O2 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0223 | PF-04991532 ≥98% (HPLC) | 1215197-37-7 | 5mg | $120 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0223 | PF-04991532 ≥98% (HPLC) | 1215197-37-7 | 25mg | $380 | 2024-03-01 | Buy |
| Tocris | 6345 | PF04991532 ≥98%(HPLC) | 1215197-37-7 | 5 | $65 | 2021-12-16 | Buy |
| Tocris | 6345 | PF04991532 ≥98%(HPLC) | 1215197-37-7 | 25 | $252 | 2021-12-16 | Buy |
| TRC | P294123 | PF04991532 | 1215197-37-7 | 25mg | $310 | 2021-12-16 | Buy |
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Chemical Properties,Uses,Production
Uses
PF 04991532 is a useful research chemical used as a hepatoselective glucokinase activator for treating type 2 diabetes mellitus.
Biological Activity
PF-04991532 is a potent and hepatoselective glucokinase activator th at reduces mean daily glucose (MDG), fasting plasma glucose (FPG) and glucose excursion in humans.
in vivo
A single dose of PF-04991532 increases the glucose infusion rate in order to maintain hyperglycemia. Despite the elevations in plasma triglycerides, surprisingly, hepatic triglycerides in rats dosed with 19 days of PF-04991532 are identical to vehicle treated GK rats. In an additional cohort treated for 28 days, identical hepatic lipid concentrations are observed between vehicle and rats dosed with PF-04991532 (Vehicle: 9.89±0.31; PF-04991532 100 mg/kg: 9.91±0.31). In rats treated with PF-04991532, there is increased expression of lipogenic gene expression such as acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY), and fatty acid synthase (FAS)[1].
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6355 | 58 | |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44814 | 58 |
View Lastest Price from (S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | PF-04991532
1215197-37-7
|
US $78.00 / mg | 10g | TargetMol Chemicals Inc. |
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- PF-04991532
1215197-37-7
- US $78.00 / mg
- TargetMol Chemicals Inc.