Regorafenib
- CAS No.
- 835621-08-4
- Chemical Name:
- Regorafenib
- Synonyms
- Regorafenib mesylate;Regorafenib (methanesulfonate)
- CBNumber:
- CB02642550
- Molecular Formula:
- C22H19ClF4N4O6S
- Molecular Weight:
- 578.92
- MDL Number:
- MOL File:
- 835621-08-4.mol
Regorafenib Chemical Properties,Uses,Production
Uses
BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.
Definition
ChEBI: Regorafenib is a pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor and a hepatotoxic agent. It is an aromatic ether, a pyridinecarboxamide, a member of monochlorobenzenes, a member of (trifluoromethyl)benzenes, a member of monofluorobenzenes and a member of phenylureas.
in vivo
Regorafenib mesylate (10 mg/kg, Orally, single dose or daily for 4 days) inhibits tumor vasculature and tumor growth in a rat GS9L glioblastoma model[1].
Regorafenib mesylate (0-100 mg/kg, Orally, qd × 9) exhibits antitumorigenic and antiangiogenic effects in the Colo-205, MDA-MB-231 and 786-O model[1].
| Animal Model: | Rat GS9L glioblastoma xenograft[1] |
| Dosage: | 10 mg/kg |
| Administration: | Orally, single dose or daily for 4 days |
| Result: | Inhibited tumor vasculature and tumor growth in a rat GS9L glioblastoma model. |
| Animal Model: | Female athymic NCr nu/nu mice, Multiple xenograft models, including models derived from CRC (Colo-205), BC (MDA-MB-231) and RCC (786-O) tumors[1] |
| Dosage: | 0, 3, 10, 30, 100 mg/kg |
| Administration: | Orally, qd × 9 |
| Result: | Effectively inhibited growth of the Colo-205, MDA-MB-231 and 786-O model. Significantly reduces tumor MVA, effectively inhibited the RAF/MEK/ERK signaling cascade, and drastically inhibited tumor cell proliferation. |
IC 50
Tie2: 311 ± 46 nM (IC50); Raf-1: 2.5 ± 0.6 nM (IC50); VEGFR2: 4.2 ± 1.6 nM (IC50); VEGFR1: 13 ± 0.4 nM (IC50); BRafV600E: 19 ± 6 nM (IC50); PDGFRβ: 22 ± 3 nM (IC50); B-Raf: 28 ± 10 nM (IC50); VEGFR3: 46 ± 10 nM (IC50)
Regorafenib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19906 | 58 |
| Shanghai Hanhong Scientific Co., Ltd. | +undefined17612118332 | Lucky@hanhonggroup.com | China | 6035 | 58 |
| Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 | sales@trio-pharmatech.com (International market) | China | 1856 | 62 |
| SYN|thesis med chem P/L | +86-021-50720296 | service@synkinase.com | China | 266 | 58 |
| Raw material medicin reagent co.,Ltd | sales@njromanme.com | China | 4529 | 58 | |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17987 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20568 | 58 |
View Lastest Price from Regorafenib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | Regorafenib mesylate
835621-08-4
|
US $1980.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-11-19 | Regorafenib
835621-08-4
|
US $0.00 / g | 1g | 98% HPLC | 1kg | shandong perfect biotechnology co.ltd |
-
- Regorafenib mesylate
835621-08-4
- US $1980.00-1520.00 / mg
- TargetMol Chemicals Inc.
-
- Regorafenib
835621-08-4
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd