3-(4-Pyridyl)indole
- CAS No.
- 7272-84-6
- Chemical Name:
- 3-(4-Pyridyl)indole
- Synonyms
- 3-(4-Pyridyl);3-(4-Pyridinyl)-;ROCK Inhibitor III;3-(4-Pyridyl)indole;Rho Kinase Inhibitor III;3-(4-Pyridinyl)-1H-indole;1H-Indole, 3-(4-pyridinyl)-;Rho Kinase Inhibitor III, Rockout;RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT;Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
- CBNumber:
- CB01564970
- Molecular Formula:
- C13H10N2
- Molecular Weight:
- 194.23
- MDL Number:
- MOL File:
- 7272-84-6.mol
- MSDS File:
- SDS
| storage temp. | +2C to +8C |
|---|---|
| solubility | DMSO, Methanol |
| form | Yellow solid |
| color | Yellow |
| Stability | Light Sensitive |
| CAS DataBase Reference | 7272-84-6 |
| UNSPSC Code | 12352200 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P321-P330-P362+P364-P501 | |||||||||
| NFPA 704 |
|
3-(4-Pyridyl)indole price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 555553 | Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem | 7272-84-6 | 10mg | $159 | 2024-03-01 | Buy |
| Cayman Chemical | 17922 | 3-(4-Pyridyl)indole ≥98% | 7272-84-6 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17922 | 3-(4-Pyridyl)indole ≥98% | 7272-84-6 | 10mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 17922 | 3-(4-Pyridyl)indole ≥98% | 7272-84-6 | 25mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 17922 | 3-(4-Pyridyl)indole ≥98% | 7272-84-6 | 50mg | $283 | 2024-03-01 | Buy |
3-(4-Pyridyl)indole Chemical Properties,Uses,Production
Description
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.
Chemical Properties
Yellow Solid
Uses
A cell-permeable indolopyridine compound that acts as a selective, ATP-competitive inhibitor of Rho kinase (ROCK) activity.
Uses
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.[Cayman Chemical]
Definition
ChEBI: 3-pyridin-4-yl-1H-indole is a member of indoles.
General Description
A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 μM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 = ~5 μM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 μM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 μM.
Biochem/physiol Actions
Cell permeable: yes
References
[1] yarrow j c, totsukawa g, charras g t, et al. screening for cell migration inhibitors via automated microscopy reveals a rho-kinase inhibitor[j]. chemistry & biology, 2005, 12(3): 385-395.
[2] amano m, fukata y, kaibuchi k. regulation and functions of rho-associated kinase[j]. experimental cell research, 2000, 261(1): 44-51.
3-(4-Pyridyl)indole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Biokitchen | 021-021-021-31663258 13795219287 | donghuanwen@126.com | China | 9523 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
View Lastest Price from 3-(4-Pyridyl)indole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-22 | 3-(4-Pyridyl)indole
7272-84-6
|
US $0.37 / g | 1g | 99% | 10kg,100kg Cherry 0956 | Career Henan Chemica Co |
-
- 3-(4-Pyridyl)indole
7272-84-6
- US $0.37 / g
- 99%
- Career Henan Chemica Co