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ChemicalBook >> CAS DataBase List >>2'',3'',5''-Triacetyl -azacytidine

2'',3'',5''-Triacetyl -azacytidine

CAS No.
10302-78-0
Chemical Name:
2'',3'',5''-Triacetyl -azacytidine
Synonyms
Nsc291930;-O-triacetate;Triacetyl azacitidine;Azacitidine Triacetate;Azacitidine Impurity 48;Intermediate of Azacitidine;2'3'5'-triacetyl-5-Azacytosine;2',3',5'-triacetyl-5-Azacytidine;2',3',5'-Tri-O-Acetyl-Azacytidine;2'',3'',5''-Triacetyl -azacytidine
CBNumber:
CB01564248
Molecular Formula:
C14H18N4O8
Molecular Weight:
370.31
MDL Number:
MFCD11113159
MOL File:
10302-78-0.mol
Last updated:2025-05-30 20:28:15

2'',3'',5''-Triacetyl -azacytidine Properties

Boiling point 497.3±55.0 °C(Predicted)
Density 1.60±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form crystalline solid
pka 3.06±0.20(Predicted)
CAS DataBase Reference 10302-78-0

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2'',3'',5''-Triacetyl -azacytidine price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13373 2',3',5'-triacetyl-5-Azacytidine ≥95% 10302-78-0 5mg $62 2024-03-01 Buy
Cayman Chemical 13373 2',3',5'-triacetyl-5-Azacytidine ≥95% 10302-78-0 10mg $115 2024-03-01 Buy
Cayman Chemical 13373 2',3',5'-triacetyl-5-Azacytidine ≥95% 10302-78-0 50mg $477 2024-03-01 Buy
Cayman Chemical 13373 2',3',5'-triacetyl-5-Azacytidine ≥95% 10302-78-0 100mg $834 2024-03-01 Buy
TRC A796030 5-Azacytidine2’,3’5’-O-triacetate 10302-78-0 50mg $265 2021-12-16 Buy
Product number Packaging Price Buy
13373 5mg $62 Buy
13373 10mg $115 Buy
13373 50mg $477 Buy
13373 100mg $834 Buy
A796030 50mg $265 Buy

2'',3'',5''-Triacetyl -azacytidine Chemical Properties,Uses,Production

Description

5-Azacytidine is an inhibitor of DNA methyltransferase, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.

Chemical Properties

White to off-white powder

Uses

5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]

in vivo

in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].

References

[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.

2'',3'',5''-Triacetyl -azacytidine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 116)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20228 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21626 55
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32283 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10244 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58

View Lastest Price from 2'',3'',5''-Triacetyl -azacytidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'',3'',5''-Triacetyl -azacytidine pictures 2025-05-30 2'',3'',5''-Triacetyl -azacytidine
10302-78-0
 US $0.00-0.00 / G 1G 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
2',3',5'-triacetyl-5-Azacytidine pictures 2025-05-21 2',3',5'-triacetyl-5-Azacytidine
10302-78-0
 US $48.00-131.00 / mg 98.34% 10g TargetMol Chemicals Inc.
2'',3'',5''-Triacetyl -azacytidine pictures 2025-05-12 2'',3'',5''-Triacetyl -azacytidine
10302-78-0
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2'',3'',5''-Triacetyl -azacytidine Spectrum

2'',3'',5''-Triacetyl -azacytidine 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-acetyl-.beta.-D-ribofuranosyl)- Nsc291930 S-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-, triacetate (ester) 2',3',5'-triacetyl-5-Azacytidine 1,3,5-Triazin-2(1H)-one, 4-aMino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)- (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate Intermediate of Azacitidine 2'3'5'-triacetyl-5-Azacytosine 2',3',5'-Tri-O-Acetyl-Azacytidine Azacitidine Triacetate Triacetyl azacitidine 2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)- -O-triacetate 4-Amino-1-(2,3,5-tri-o-acetyl-beta-d-ribofuranosyl)-1,3,5-triazin-2(1h)-one 5-Azacytidine 2’,3’5’-O-triacetate Azacitidine Impurity 48 2'',3'',5''-Triacetyl -azacytidine 2',3',5'-Tri-O-acetyl-5-azacytidine triethylenetetramine-N,N,N',N'',N''' 2'',3'',5''-triacetyl-5-Azacytidine 2'',3'',5''-triacetyl-5-Azacytidine, 10 mM in DMSO 2′,3′,5′-Triacetyl-azacytidine, CAS 10302-78-0 10302-78-0