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Biomolecules

Biomolecules

IF: 4.79
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Recent Advances in Peptidoglycan Synthesis and Regulation in Bacteria.

Published:22 April 2023 DOI: 10.3390/biom13050720 PMID: 37238589
Anne Galinier, Clémentine Delan-Forino, Elodie Foulquier, Hakima Lakhal, Frédérique Pompeo

Abstract

Bacteria must synthesize their cell wall and membrane during their cell cycle, with peptidoglycan being the primary component of the cell wall in most bacteria. Peptidoglycan is a three-dimensional polymer that enables bacteria to resist cytoplasmic osmotic pressure, maintain their cell shape and protect themselves from environmental threats. Numerous antibiotics that are currently used target enzymes involved in the synthesis of the cell wall, particularly peptidoglycan synthases. In this review, we highlight recent progress in our understanding of peptidoglycan synthesis, remodeling, repair, and regulation in two model bacteria: the Gram-negative Escherichia coli and the Gram-positive Bacillus subtilis. By summarizing the latest findings in this field, we hope to provide a comprehensive overview of peptidoglycan biology, which is critical for our understanding of bacterial adaptation and antibiotic resistance.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
PEPTIDOGLYCAN 27814-48-8 C3H5NO4 66 suppliers Inquiry
Bacillus subtilis 26 suppliers Inquiry
ESCHERICHIA COLI 24 suppliers $257.00-$3911.12

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