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ChemicalBook >> CAS DataBase List >>Nimesulide

Nimesulide

CAS No.
51803-78-2
Chemical Name:
Nimesulide
Synonyms
Nimesulide-d5;N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE;Nide;Nidol;nimed;AULIN;R-805;Aufin;Nisuli;MESULID
CBNumber:
CB0138084
Molecular Formula:
C13H12N2O5S
Molecular Weight:
308.31
MDL Number:
MFCD00079470
MOL File:
51803-78-2.mol
MSDS File:
SDS
Last updated:2024-12-18 13:37:16

Nimesulide Properties

Melting point 140-146°C
Boiling point 442.0±55.0 °C(Predicted)
Density 1.451±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
form Solid
pka pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
color Light orange to Yellow to Green
Water Solubility Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax 391nm(H2O)(lit.)
Merck 14,6548
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference 51803-78-2(CAS DataBase Reference)
FDA UNII V4TKW1454M
ATC code M01AX17,M02AA26
EPA Substance Registry System Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310+P330
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  PB0970000
HS Code  2935.90.9500
HazardClass  6.1
PackingGroup  III
Toxicity LD50 orally in rats: 324 mg/kg (Swingle, Moore)
NFPA 704
0
2 0

Nimesulide price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N1016 Nimesulide 51803-78-2 1g $30.7 2024-03-01 Buy
Sigma-Aldrich N1016 Nimesulide 51803-78-2 5g $109 2024-03-01 Buy
TCI Chemical N0984 Nimesulide >98.0%(HPLC)(T) 51803-78-2 1g $20 2024-03-01 Buy
TCI Chemical N0984 Nimesulide >98.0%(HPLC)(T) 51803-78-2 5g $53 2024-03-01 Buy
Alfa Aesar J63699 Nimesulide 51803-78-2 5g $53.65 2024-03-01 Buy
Product number Packaging Price Buy
N1016 1g $30.7 Buy
N1016 5g $109 Buy
N0984 1g $20 Buy
N0984 5g $53 Buy
J63699 5g $53.65 Buy

Nimesulide Chemical Properties,Uses,Production

Description

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 μM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC50s = 70 and 22 μM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 μM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; ) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.

Description

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Chemical Properties

Yellow Needle-Like Crystals

Originator

Riker (USA)

Uses

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Uses

Antiinflammatory;'Cyclooxygenase 2 inhibitor

Uses

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]

Uses

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

Uses

Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production

Uses

Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.

Definition

ChEBI: Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a C-nitro compound, a sulfonamide and an aromatic ether. It is functionally related to a nitrobenzene.

brand name

Nimulid.

General Description

Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.

Biochem/physiol Actions

Highly selective cyclooxygenase-2 inhibitor.

Clinical Use

Nimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.

References

https://en.wikipedia.org/wiki/Nimesulide
https://www.drugbank.ca/drugs/DB04743

Global( 568)Suppliers
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Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
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Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58

View Lastest Price from Nimesulide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nimesulide pictures 2024-12-13 Nimesulide
51803-78-2
 US $0.00 / Kg/Drum 25KG 98% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Nimesulide pictures 2024-11-20 Nimesulide
51803-78-2
 US $1.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
Nimesulide pictures 2024-11-19 Nimesulide
51803-78-2
 US $30.00-50.00 / mg 99.91% 10g TargetMol Chemicals Inc.
  • Nimesulide pictures
  • Nimesulide
    51803-78-2
  • US $0.00 / Kg/Drum
  • 98%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Nimesulide pictures
  • Nimesulide
    51803-78-2
  • US $1.00 / KG
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd
  • Nimesulide pictures
  • Nimesulide
    51803-78-2
  • US $30.00-50.00 / mg
  • 99.91%
  • TargetMol Chemicals Inc.

Nimesulide Spectrum

nimed 4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD) CETIRIZINE DIHYDROCHLORIDE IMP. E (EP):(RS)-2-[2-[2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHOXY]ETHOXY]ACETIC ACID MM(CRM STANDARD) CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD) 4-Nitro-2-phenoxymethanesulfonamide Nide Nidol Nisuli Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE(NIMESULIDE) MESULID AULIN FANSIDOL Nimesulide,N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide Nimesulide for peak identification Lizepat 4-Nitro-2-(phenoxy-d5) MethanesulfonaMide-d5 4'-Nitro-2'-(phenoxy-d5)Methanesulfonanilide Aulin-d5 Flogovital-d5 Lizepat-d5 N-(4-Nitro-2-(phenoxy-d5)phenyl)MethanesulfonaMide sulidene Nisulid N-(4-NITRO-2-PHENOXY)METHANESULFONANILIDE NIMESULIDE R-805 4’-nitro-2’-phenoxy-methanesulfonanilid 4-nitro-2-phenoxy-methanesulfonanilide flogovital n-(4-nitro-2-phenoxyphenyl)-methanesulfonamid Aufin N-(4-Nitro-2-phenoxyphenyl)methanesulphonamide Nimesulide > Nimesulide for peak identification CRS Nimesulide CRS Nimesulide USP/EP/BP Nimesulide (R805) Nimesulli Nimesulide, GR Nimesulide (N0845000) Nimesulide for peak identification (Y0001237) NimesulideQ: What is Nimesulide Q: What is the CAS Number of Nimesulide Q: What is the storage condition of Nimesulide N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE Nimesulide-d5 MESULID Powder USP Standard nimesulin Nimesulide (BP) 4'-Hydroxy Nimesulide-d4 Nimesulide in Acetonitrile 51803-78-2 74110-35-9 C13H7N2O5SD5 C13H7D5N2O5S Cell Signaling Enzymes BioChemical Application Index