INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2601727-80-2
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- MS4322;(Iso)-MS4322;6-{[1-(1-{[(2R)-1-[(2S,4R)-4-hydroxy-2-{[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-2,5,8,11,14-pentaoxahexadecanoyl)azetidin-3-yl]amino}-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide
- CBNumber:
- CB010824380
- Molecular Formula:
- C55H76N10O12S
- Molecular Weight:
- 1101.33
- MDL Number:
- MOL File:
- 2601727-80-2.mol
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Description
MS4322 is a potent PRMT5 degrader.
Uses
MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 ))[1].
IC 50
VHL; Cereblon; MDM2; SMYD2; SMYD3; EHMTI PEP; SETD7/KMT7; PRMT4; PRMT8; EZH1; SETDB1/KMT2G; SETD8/KMT5A; PRMT5; EZH2; SUV39H2/KMT1B; SETD2/KMT3A; PRMT1; PRMT6; DOT1L; EHMT2/G9a/KMT1C; NSD2; PRMT3; PRMT7
References
[1] Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63(17):9977-9989. DOI:10.1021/acs.jmedchem.0c01111
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32285 | 58 |
| Zepeptide Biotechnology (Shijiazhuang) Co., Ltd | +86-86-13383293380 +8613230482270 | 1919301810@qq.com | China | 141 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3474 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 7989 | 62 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1592 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3640 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4593 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24897 | 58 |
| Zhengzhou Lingzhiyue Technology Co., LTD | +86-0371-55074660 | Lingzhiyue@aliyun.com | China | 4739 | 58 |
| Zhengzhou Converging Chemical Co. LTD | 0371-53399770 18037166334 | 2853031800@qq.com | China | 4640 | 58 |
View Lastest Price from INDEX NAME NOT YET ASSIGNED manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-07 | (Iso)-MS4322
2601727-80-2
|
US $489.00-1570.00 / mg | 99.76% | 10g | TargetMol Chemicals Inc. |
-
- (Iso)-MS4322
2601727-80-2
- US $489.00-1570.00 / mg
- 99.76%
- TargetMol Chemicals Inc.