4-(4-CHLORO-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID synthesis

4synthesis methods

Product Name:4-(4-CHLORO-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID
CAS Number:3648-57-5
Molecular formula:C12H13ClO3
Molecular Weight:240.68

3648-74-6 Synthesis

4-(4-Chloro-phenyl)-tetrahydro-pyran-4-carbonitrile

3648-74-6
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4-(4-CHLORO-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID

3648-57-5
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$200.00/500mg

Yield:3648-57-5 85%

Reaction Conditions:

with potassium hydroxide;water for 5 h;Heating / reflux;

Steps:

1.1.2

[step 2] To a suspension of 4-(4-chlorophenyl)tetrahydro-2H-pyran-4-carbonitrile (2.6 g) obtained in the above-mentioned step 1 in water (50 ml) was added potassium hydroxide (3.3 g, 5.0 eq), and the mixture was heated under reflux for 5 hr. The reaction mixture was extracted with chloroform (100 ml×2). The organic layer was washed with saturated brine (50 ml), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was crystallized from diisopropyl ether/hexane, and the crystals were collected by filtration to give the object product (2.0 g, yield 85%).

References:

EP2060563,2009,A1 Location in patent:Page/Page column 19

3648-74-6 Synthesis

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111-46-6 Synthesis