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Mesna

Mesna Struktur
19767-45-4
CAS-Nr.
19767-45-4
Bezeichnung:
Mesna
Englisch Name:
Mesna
Synonyma:
SODIUM 2-MERCAPTOETHANESULFONATE;mesnaum;COENZYME M;SodiuM 2-Mercaptoethanesulfonate (Mesna);2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT;MESNA;MESNEX;mesnum;D 7093;Mesina
CBNumber:
CB7277461
Summenformel:
C2H7NaO3S2
Molgewicht:
166.18
MOL-Datei:
19767-45-4.mol

Mesna Eigenschaften

Schmelzpunkt:
>240°C dec.
storage temp. 
2-8°C
L?slichkeit
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in cyclohexane
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserl?slichkeit
Soluble in water. Also soluble in methanol, DMSO (33 mg/ml) and ethanol (<1 mg/ml).
Merck 
14,5909
BRN 
3657828
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
CAS Datenbank
19767-45-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  2
RTECS-Nr. KI7968000
HS Code  2930 90 98
Toxizit?t LD50 in male, female mice, male, female rats (mg/kg): 1887, 2048, 2098, 1683 i.v.; 2005, 2098, 1529, 1251 i.p.; 6102, >7200, 4440, 4679 orally (Brock)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Mesna Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Mesna reacts with acrolein and other urotoxic metabolites of oxazaphosphorines (cyclophosphamide or ifosfamide) to form stable, non-urotoxic compounds. Mesna does not have any antitumour activity, nor does it appear to interfere with the antitumour activity of antineoplastic drugs. This medication is used to protect the bladder wall from the harmful effects of some cancer-fighting drugs.

Weltgesundheitsorganisation (WHO)

Mesna, an antidote used to protect patients treated with cyclophosphamide or ifosfamide from haemorrhagic vesiculitis, was introduced on the market in 1984. Shortly afterwards, its use became associated with allergic reactions, which occurred mainly in patients treated with the oral solution. This led to the withdrawal of this formulation in Germany, the only country where it was marketed. An oral liquid dosage form is still registered, but not marketed, in the Netherlands and products for intravenous injection remain available elsewhere.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Kontakt-Allergie

Mesna is used as a mucolytic agent, and as an antidote to chloro-acetyl-aldehyde and acrolein (a bladder toxic metabolite of ifosfamide or cyclophosphamide). It hasbeen reported as a cause of occupational allergic (hand and airborne) dermatitis in nurses

l?uterung methode

It can be recrystallised from H2O and does not melt below 250o. It is purified further by converting to the free acid by passing a 2M solution through an ion-exchange (Amberlite IR-120) column in the acid form, evaporating the eluate in a vacuum to give the acid as a viscous oil (readily decomposes) which can be checked by acid and SH titration. It is then dissolved in H2O, carefully neutralised with aqueous NaOH, evaporated and the salt recrystallised from H2O [Schramm J Am Chem Soc 77 6231 1955]. [Beilstein 4 IV 85.]

Mesna Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Mesna Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 436)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 11818 58

19767-45-4(Mesna)Verwandte Suche:


  • 2-mercaptoethanesulfonic
  • 2-mercaptoethanesulfonicacidmonosodiumsalt
  • MERCAPTOETHANESULFONIC ACID SODIUM SALT
  • MESNA SODIUM SALT
  • MESNEX
  • MESNA
  • COENZYME M SODIUM SALT
  • HS-COM NA
  • 2-MERCAPTOETHANESULFONIC ACID SODIUM
  • 2-MERCAPTOETHANESULFONIC ACID SODIUM SALT
  • MesnaEp5
  • Sodium mercaptoethanesulfonate
  • Mesna(FDA)
  • 2-MERCAPTOETHANESULFONIC ACID SODIUM SALT 95+%
  • Ethanesulfonic acid, 2-mercapto-, monosodium salt
  • MESNA(2-MERCAPTOETHANESULFONICACIDSODIUMSALT)
  • BETA-MERCAPTOETHANESULPHONICACIDSODIUMSALT
  • SODIUMMERCAPTOETHANESULPHONATE
  • SODIUM2-MERCAPTOETHANESULPHONATE
  • 2-MERCAPTOETHANESULPHONATE,SODIUMSALT
  • 2-MERCAPTOETHANESULFONIC ACID SODIUM SALT EP5
  • Mesna(sodium 2-mercaptoethanesulfonate)
  • 2-Mercapto-1-ethanesulfonic Acid Monosodium Salt
  • Mesna:Sodium 2-mercaptoethanesulphonate
  • 2-mercapto-ethanesulfonicacimonosodiumsalt
  • mesnum
  • mistabron
  • mitexan
  • mucofluid
  • uromitexan
  • D 7093
  • Mistabronco
  • UCB 3983
  • 2-Mercaptoethanesulfonic acid sodium salt, Coenzyme M sodium salt, HS-CoM Na, MESNA
  • 2- Mercaptothanesulfonic Acid Sodium Salt
  • MESNA (2-Mercaptoethanesulfonate sodiuM)
  • Mesna (200 mg)
  • sodiuM 1-sulfanyl-2-sulfoethyliuM
  • 2-(acetylthio)ethanesulfonic acid
  • 2-Mercaptoethanesulfonic-d4-acid sodiuM salt (MESNA-d4)
  • Mesna(UroMitexan, Mesnex)
  • Mesna API
  • 2-Mercaptoethanesulfonic Acid Sodium Salt Mesna
  • SODIUM 2-MERCAPTOETHANESULFONATE FOR SYN
  • 2-Mercaptoethanesulfonic,Mesna
  • Mesna (1392807)
  • Mesna USP/EP/BP
  • Ethanesulfonic acid, 2-mercapto-, sodium salt (1:1)
  • 2-mercaptoethanesulphonate
  • Sodium2-Mercaptoethanesulfonate>
  • mesnaum
  • COENZYME M
  • 2-MERCAPTOETHANESULPHONIC ACID SODIUM SALT
  • SODIUM 2-MERCAPTOETHANESULFONATE
  • SodiuM 2-Mercaptoethanesulfonate (Mesna)
  • The department of sodium
  • Mesna Powder USP Standard
  • Mesina
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