Ginkgolide J NEW
| Price | $92 | $220 | $325 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ginkgolide J | CAS No.: 107438-79-9 |
| Purity: 99.83% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ginkgolide J |
| Description | Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. |
| Cell Research | Hippocampal cultures were treated by adding 10 μM Aβ1-42 in its oligomeric form with or without P8A, or alternatively with and without each of the individual ginkgolides and bilobalide (GA, GB, GC GJ, BB).??these compounds were dissolved in DMSO and added to the culture medium at a ratio of 1:1000 (v/v), yielding a 0.1% DMSO solution.?After 24 hrs the number of viable cells was assessed by nuclear counting.?In a separate set of experiments, viable cells were counted by using the ethidium homodimer/calcein-AM combination of vital dyes (LIVE/DEAD Viability/Cytotoxicity Kit for mammalian cells;?Invitrogen), according to the manufacturer instructions.?Values represent the mean SEM of three consecutive experiments.?Each experiment was performed in triplicate[1]. |
| In vitro | A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neuroprotective effect is attributed in large part to Ginkgolide J that completely replicates the effect of the extract. Ginkgolide J is also capable of inhibiting cell death of rodent hippocampal neurons caused by A beta[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/ml (141.38 mM) |
| Keywords | inhibit | 7-β-Hydroxyginkgolide A | Ginkgolide J | BN52024 | BN-52024 | Inhibitor | 7-b-Hydroxyginkgolide A |
| Inhibitors Related | Theophylline monohydrate | Tadalafil | Roflumilast | Luteolin | Apremilast | Isoprenaline hydrochloride | Indomethacin | Mirodenafil dihydrochloride | Icariin | Theophylline | Vardenafil hydrochloride | Doxofylline |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Natural Product Library | Neuroprotective Compound Library | Anti-Cardiovascular Disease Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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