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ChemicalBook--->CAS DataBase List--->11052-72-5

11052-72-5

11052-72-5 Structure

11052-72-5 Structure
IdentificationBack Directory
[Name]

OLIGOMYCIN C
[CAS]

11052-72-5
[Synonyms]

Oligmycin C
OLIGOMYCIN C
12-Deoxyoligomycin A
Oligomycin A, 12-deoxy-
OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)-
[EINECS(EC#)]

234-276-0
[Molecular Formula]

C45H74O10
[MDL Number]

MFCD00043231
[MOL File]

11052-72-5.mol
[Molecular Weight]

775.06
Chemical PropertiesBack Directory
[Boiling point ]

876.2±65.0 °C(Predicted)
[density ]

1.091 g/cm3
[storage temp. ]

−20°C
[solubility ]

Soluble in DMSO
[form ]

White to off-white powder.
[pka]

13.49±0.70(Predicted)
[Merck ]

13,6902
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22
[RIDADR ]

2811
[RTECS ]

RK3335000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

2941900000
[Toxicity]

LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958
Hazard InformationBack Directory
[Description]

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.
[Uses]

Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
[Safety Profile]

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors
[References]

[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.
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