LY2365109鹽酸鹽
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- CAS號:
- 1779796-27-8
- 英文名:
- LY2365109 (hydrochloride)
- 英文別名:
- LY2365109 HCl;LY2365109 hydrochloride, 10 mM in DMSO;2-((2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)(methyl)amino)acetic acid hydrochloride;neuroblastoma,Glycine transporters,LY2365109,Human,GlyT,LY-2365109 hydrochloride,LY 2365109,glycine,seizure,LY2365109 hydrochloride,LY-2365109,uptake,Inhibitor,inhibit
- 中文名:
- LY2365109鹽酸鹽
- 中文別名:
- LY2365109鹽酸鹽;LY2365109鹽酸鹽,10 MM DMSO 溶液;2-((2-(4-(苯并[D][1,3]二氧雜戊環(huán)-5-基)-2-(叔丁基)苯氧基)乙基)(甲基)氨基)乙酸鹽酸鹽
- CBNumber:
- CB83146615
- 分子式:
- C22H28ClNO5
- 分子量:
- 421.92
- MOL File:
- 1779796-27-8.mol
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LY2365109鹽酸鹽化學性質(zhì)
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儲存條件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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Soluble to 100 mM in DMSO and to 50 mM in ethanol
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形態(tài):
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Solid
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顏色:
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White to off-white
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LY2365109鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
LY2365109 hydrochloride 是一種高效、選擇性的 GlyT1 抑制劑，抑制過表達 hGlyT1 細胞攝取谷氨酸的 IC50 值為 15.8 nM.
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hGlyT1
15.8 nM nM (IC
50
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LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.
LY2365109 hydrochloride increases seizure thresholds in mice.
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Animal Model:
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Male Sprague-Dawley rats (250-300 g)
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Dosage:
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0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg
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Administration:
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Oral administration
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Result:
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Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.
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LY2365109鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
1779796-27-8, LY2365109鹽酸鹽 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- LY2365109鹽酸鹽,10 MM DMSO 溶液
- 2-((2-(4-(苯并[D][1,3]二氧雜戊環(huán)-5-基)-2-(叔丁基)苯氧基)乙基)(甲基)氨基)乙酸鹽酸鹽
- LY2365109鹽酸鹽
- 1779796-27-8
- LY2365109 hydrochloride, 10 mM in DMSO
- 2-((2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)(methyl)amino)acetic acid hydrochloride
- neuroblastoma,Glycine transporters,LY2365109,Human,GlyT,LY-2365109 hydrochloride,LY 2365109,glycine,seizure,LY2365109 hydrochloride,LY-2365109,uptake,Inhibitor,inhibit
- LY2365109 HCl