硫酸碘芐胍 EP標(biāo)準(zhǔn)品
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- CAS號(hào):
- 87862-25-7
- 英文名:
- 3-IODOBENZYL-GUANIDINE HEMISULFATE
- 英文別名:
- M-IBG;MIBG sulfate;MIBG hemisulfate;MIBG HEMISULFATE SALT;Iobenguane sulfate CRS;Iobenguane Hemisulfate;Nafamostat Impurity 14;m-iodobenzylguanidine sulfate;M-IODOBENZYLGUANIDINE 1/2H2SO4;Iobenguane sulfate, 10 mM in DMSO
- 中文名:
- 硫酸碘芐胍 EP標(biāo)準(zhǔn)品
- 中文別名:
- 3-碘芐胍硫酸鹽;萘伐莫司他雜質(zhì)14;硫酸碘芐胍 EP標(biāo)準(zhǔn)品;1-(3-碘芐基)胍半硫酸鹽;IOBENGUANE HEMISULFATE;硫酸碘芐胍 EP標(biāo)準(zhǔn)品,10 MM DMSO 溶液
- CBNumber:
- CB8278137
- 分子式:
- C16H22I2N6O4S
- 分子量:
- 648.26
- MOL File:
- 87862-25-7.mol
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硫酸碘芐胍 EP標(biāo)準(zhǔn)品化學(xué)性質(zhì)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
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形態(tài):
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A crystalline solid
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顏色:
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White to off-white
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硫酸碘芐胍 EP標(biāo)準(zhǔn)品性質(zhì)、用途與生產(chǎn)工藝
Iobenguane sulfate (MIBG sulfate) 是一種具有抗腫瘤活性的神經(jīng)遞質(zhì)去甲腎上腺素的類似物。放射性碘代 Iobenguane sulfate 可用于腎上腺腫瘤診斷和腫瘤靶向藥物的研究。Iobenguane sulfate 是一種高親和力的霍亂毒素底物，干擾細(xì)胞單核(ADP-核糖基化)。
Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines.
Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range.
Cell Proliferation Assay
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Cell Line:
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3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells
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Concentration:
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2, 20μg/ml
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Incubation Time:
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72 hours
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Result:
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Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth.
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Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity.
The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed.
Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg.
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Animal Model:
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DBA/2 (L1210)) mice
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Dosage:
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i.p.; daily on days 3-6
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Administration:
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20 mg/kg
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Result:
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Considerable prolongation of survival and some cures were obtained.
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硫酸碘芐胍 EP標(biāo)準(zhǔn)品
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
硫酸碘芐胍 EP標(biāo)準(zhǔn)品
生產(chǎn)廠家
87862-25-7, 硫酸碘芐胍 EP標(biāo)準(zhǔn)品 相關(guān)搜索:
- 抑制劑
- 高端化學(xué)
- C8H10IN312H2SO4
- 硫酸碘芐胍 EP標(biāo)準(zhǔn)品,10 MM DMSO 溶液
- 萘伐莫司他雜質(zhì)14
- 3-碘芐胍硫酸鹽
- 1-(3-碘芐基)胍半硫酸鹽
- IOBENGUANE HEMISULFATE
- 硫酸碘芐胍 EP標(biāo)準(zhǔn)品
- 87862-25-7
- m-Iodobenzylguanidine hemisulfate salt
- Iobenguane sulfate, 10 mM in DMSO
- Guanidine, N-[(3-iodophenyl)methyl]-, sulfate (2:1)
- Nafamostat Impurity 14
- proliferation,survival,tumors,MIBG,Iobenguane,mono(ADP-ribosylation),Iobenguane sulfate,inhibit,cytotoxic,analogue,antitumor,Inhibitor,adrenergic
- Guanidine,[(3-iodChemicalbookophenyl)methyl]-,sulfate(2:1)
- Iobenguane sulfate，m-Iodobenzylguanidine (hemisulfate)
- m-Iodo benzyl guanidine, hemisulphate, 99%
- 1-(3-Iodobenzyl)guanidine hemis ulfate
- MIBG sulfate
- Iobenguane Hemisulfate
- Iobenguane sulfate CRS
- 3-IODOBENZYL-GUANIDINE HEMISULFATE
- 3-IODOBENZYLGUANIDINE HEMISULPHATE
- m-iodobenzylguanidine sulfate
- MIBG hemisulfate
- meta-Iodobenzylguanidine hemisulfate
- Guanidine, [(3-iodophenyl)methyl]-, sulfate (2:1)
- M-IODOBENZYLGUANIDINE 1/2H2SO4
- M-IODOBENZYLGUANIDINE HEMISULFATE SALT
- MIBG HEMISULFATE SALT
- M-IBG