Isocoptisine acetate
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- CAS號:
- 30426-66-5
- 英文名:
- Isocoptisine acetate
- 英文別名:
- Isocoptisine acetate;Pseudocoptisine acetate
- 中文名:
- Isocoptisine acetate
- 中文別名:
- 異黃連堿(乙酸鹽);化合物 T12570
- CBNumber:
- CB74806614
- 分子式:
- C21H17NO6
- 分子量:
- 379.37
- MOL File:
- 30426-66-5.mol
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Isocoptisine acetate化學性質(zhì)
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熔點:
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146-147 °C
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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Isocoptisine acetate性質(zhì)、用途與生產(chǎn)工藝
Pseudocoptisine (Isocoptisine) acetate 是從延胡索中分離得到的具有芐基異喹啉骨架的四元生物堿。Pseudocoptisine acetate 抑制乙酰膽堿酯酶 (AChE) 活性，IC50 為12.8μM。具有抗炎和抗遺忘作用。
Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test.
Isocoptisine acetate
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2023/03/20 | HY-N6894 | Isocoptisine acetate
Pseudocoptisine acetate | 30426-66-5 | 1mg | 7240元 |
| 2023/03/20 | HY-N6894 | Isocoptisine acetate
Pseudocoptisine acetate | 30426-66-5 | 5mg | 21710元 |
Isocoptisine acetate
生產(chǎn)廠家
30426-66-5, Isocoptisine acetate 相關(guān)搜索:
- 標準品
- 化合物 T12570
- 異黃連堿(乙酸鹽)
- 30426-66-5
- Pseudocoptisine acetate
- Isocoptisine acetate