BMS-5
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- CAS號(hào):
- 1338247-35-0
- 英文名:
- N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide
- 英文別名:
- LIMKI-3;CS-2190;BMS 5;BMS5;BMS-5 ≥95%;BMS-5, LIMKI-3;BMS-5, 10 mM in DMSO;LIMKI-3;BMS5;BMS 5;LIMKI3;LIMKI 3;LIMKi3,inhibit,LIM Kinase (LIMK),LIMKs,Inhibitor,BMS 5,BMS-5,LIMKi-3;N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide;N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide[BMS5
- 中文名:
- BMS-5
- 中文別名:
- 化合物BMS5;BMS-5游離態(tài);LIMKI 3,LIM激酶抑制劑;化合物BMS5,10 MM DMSO 溶液;N-(5-(1-(2,6-二氯苯基)-3-(二氟甲基)-1H-吡唑-5-基)噻唑-2-基)異丁酰胺
- CBNumber:
- CB72598623
- 分子式:
- C17H14Cl2F2N4OS
- 分子量:
- 431.29
- MOL File:
- 1338247-35-0.mol
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BMS-5化學(xué)性質(zhì)
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密度:
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1.54±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO:PBS (pH 7.2) (1:5):0.2(Max Conc. mg/mL);0.46(Max Conc. mM)
Ethanol:3.0(Max Conc. mg/mL);6.96(Max Conc. mM)-
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酸度系數(shù)(pKa):
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9.51±0.50(Predicted)
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形態(tài):
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White powder.
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顏色:
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White to off-white
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BMS-5性質(zhì)、用途與生產(chǎn)工藝
BMS-5 (LIMKi 3) 是一種有效的 LIM kinases (LIMK) 的抑制劑,對(duì)LIMK1和LIMK2的IC50值分別為7 nM和8 nM。
Target | Value |
LIMK1
(Cell-free assay)
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7 nM
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LIMK2
(Cell-free assay)
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8 nM
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BMS-5 (LIMKi 3) inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner in
Nf2
ΔEx2
mouse Schwann cells (MSCs) with an IC
50
of ~2 μM. BMS-5 (LIMKi 3) reduces
Nf2
ΔEx2
MSC viability in a dose-dependent manner with an IC
50
of 3.9 μM, but does not significantly reduce the viability of control
Nf2
flox2/flox2
MSCs at equivalent BMS-5 concentrations. At 10 μM BMS-5,
Nf2
ΔEx2
MSC viability is 40% compared to 83% for controls.
BMS-5 (LIMKi 3) (20 or 200 μM/side) is bilaterally infused into the hippocampus of rats immediately after contextual fear conditioning training. Rats are tested for memory consolidation 48 h after fear conditioning. Post hoc analysis shows that the group treated with 200 μM BMS-5 express lower freezing levels compared to the 20 μM and vehicle groups (P<0.01).
BMS-5
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更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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2025/05/22 | S0185 | BMS-5 BMS-5 | 1338247-35-0 | 5mg | 857.46元 |
2025/05/22 | S0185 | BMS-5 BMS-5 | 1338247-35-0 | 25mg | 1775.47元 |
1338247-35-0, BMS-5 相關(guān)搜索:
- 合成有機(jī)化合物配體
- 抑制劑
- C17H14Cl2F2N4OS
- 化合物BMS5,10 MM DMSO 溶液
- LIMKI 3,LIM激酶抑制劑
- N-(5-(1-(2,6-二氯苯基)-3-(二氟甲基)-1H-吡唑-5-基)噻唑-2-基)異丁酰胺
- 化合物BMS5
- BMS-5游離態(tài)
- 1338247-35-0
- BMS-5, 10 mM in DMSO
- LIMKi3,inhibit,LIM Kinase (LIMK),LIMKs,Inhibitor,BMS 5,BMS-5,LIMKi-3
- N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide[BMS5
- Propanamide, N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-
- LIMKI-3;BMS5;BMS 5;LIMKI3;LIMKI 3
- N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide
- N-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide
- BMS 5;BMS5
- BMS-5 ≥95%
- CS-2190
- BMS-5, LIMKI-3
- Mitoquinone mesylateN-{5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]- 1,3-thiazol-2-yl}-2-methylpropanamide
- LIMKI-3
- N-(5-(1-(2,6-dichlorophenyl)-3-(difluoroMethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyraMide