里查酮 A
|
|
|
- CAS號:
- 97938-31-3
- 英文名:
- (2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
- 英文別名:
- Leachiane A;Leachianone A;(-)-Vexibidin;Leachianone A, 10 mM in DMSO;Apoptosis,Inhibitor,Leachianone A,inhibit;2'-methoxy-5,7,4'-trihydroxy-8-lavandulylflavanone;(S)-5,7-Dihydroxy-2-(4-hydroxy-2-Methoxyphenyl)-8-((R)-5-Methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroMan-4-one;(2S)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one;(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
- 中文名:
- 里查酮 A
- 中文別名:
- 里查酮 A;異苦參酮,勒奇黃烷酮A;里查酮 A,10 MM DMSO 溶液;(S)-5,7-二羥基-2-(4-羥基-2-甲氧基苯基)-8-((R)-5-甲基-2-(丙-1-烯-2-基)己-4- 烯-1-基)苯并二氫吡喃-4-酮
- CBNumber:
- CB72218147
- 分子式:
- C26H30O6
- 分子量:
- 438.51
- MOL File:
- 97938-31-3.mol
|
|
|
里查酮 A化學(xué)性質(zhì)
-
沸點:
-
649.7±55.0 °C(Predicted)
-
|
-
密度:
-
1?+-.0.06 g/cm3(Predicted)
-
|
-
儲存條件:
-
2-8°C
-
|
-
溶解度:
-
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
-
|
-
形態(tài):
-
Powder
-
|
-
酸度系數(shù)(pKa):
-
7.67±0.40(Predicted)
-
|
-
顏色:
-
Off-white to light yellow
-
|
里查酮 A性質(zhì)、用途與生產(chǎn)工藝
Leachianone A 從槐花中分離，具有抗瘧疾，抗炎和細胞毒性作用。
Leachianone A 誘導(dǎo)細胞凋亡 (apoptosis)。
Leachianone A (0-20 μg/ml; 24-72 hours) exhibits a marked inhibition on the survival of HepG2 cells time- and dose-dependently manner, IC
50
values are 6.9 μg/ml, 3.4 μg/ml and 2.8 μg/ml in cells with 24-, 48- and 72-hours treatment, respectively.
Leachianone A (10-30 μg/ml; 48 hours) indicates that at low concentration of LA (10 μg/ml), a substantial amount of cells is primarily in the early phase of apoptosis, at higher concentrations, induces a shift of the cell population to late apoptotic/ necrotic stage.
Leachianone A (10-30 μg/ml; 48 hours) decreases the precursor of caspase-3 in a dose-dependent manner, reduces the protein level of the pro-forms of upstream initiator caspases, caspases-8 and -9, decreases two downstream substrates, namely inhibitor of caspase-activated DNase(ICAD) and poly-ADP-ribose polymerase (PARP) in HepG2 cells.
Cell Viability Assay
|
Cell Line:
|
HepG2 cells
|
|
Concentration:
|
0 μg/ml, 2 μg/ml, 4 μg/ml, 6 μg/ml, 8 μg/ml, 10 μg/ml, 12 μg/ml, 14 μg/ml, 16 μg/ml, 18 μg/ml, 20 μg/ml
|
|
Incubation Time:
|
24-72 hours
|
|
Result:
|
Inhibited HepG2 cells survival.
|
Apoptosis Analysis
|
Cell Line:
|
HepG2 cells
|
|
Concentration:
|
48 hours
|
|
Incubation Time:
|
10, 20, and 30 μg/ml
|
|
Result:
|
Induced the proportion of annexin V-stained cells in both the early and late apoptotic stage.
|
Western Blot Analysis
|
Cell Line:
|
HepG2 cells
|
|
Concentration:
|
48 hours
|
|
Incubation Time:
|
10, 20, and 30 μg/ml
|
|
Result:
|
Decreased the protein expression of caspase-3, caspases-8 and -9, reduced ICAD and PARP protein expression.
|
Leachianone A (intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days) significantly diminishes the tumor volume by 17-54% in LA-treated nude mice, when compared with those solely given the vehicle.
|
Animal Model:
|
Male nude mice with human hepatoma HepG2 cells
|
|
Dosage:
|
20 mg/kg; 30 mg/kg
|
|
Administration:
|
Intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days
|
|
Result:
|
Suppressed the tumor growth in vivo.
|
里查酮 A
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/05/22 | HY-N2281 | 里查酮 A
Leachianone A | 97938-31-3 | 1mg | 900元 |
| 2025/05/22 | HY-N2281 | 里查酮 A
Leachianone A | | 10 mM * 1 mLin DMSO | 2315元 |
97938-31-3, 里查酮 A 相關(guān)搜索:
- 抑制劑
- 黃酮
- 標準品 -對照藥材
- 植物提取物
- 標準品
- 里查酮 A,10 MM DMSO 溶液
- 異苦參酮,勒奇黃烷酮A
- (S)-5,7-二羥基-2-(4-羥基-2-甲氧基苯基)-8-((R)-5-甲基-2-(丙-1-烯-2-基)己-4- 烯-1-基)苯并二氫吡喃-4-酮
- 里查酮 A
- 97938-31-3
- Leachianone A, 10 mM in DMSO
- Apoptosis,Inhibitor,Leachianone A,inhibit
- (2S)-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one
- 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-
- (-)-Vexibidin
- 2'-methoxy-5,7,4'-trihydroxy-8-lavandulylflavanone
- (S)-5,7-Dihydroxy-2-(4-hydroxy-2-Methoxyphenyl)-8-((R)-5-Methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroMan-4-one
- Leachiane A
- Leachianone A
- (2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one