MI-3 (Menin-MLL Inhibitor)
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- CAS號:
- 1271738-59-0
- 英文名:
- MI-3 (Menin-MLL Inhibitor)
- 英文別名:
- MI-3;CS-1809;5-dihydro-5;MI-3, 10 mM in DMSO;Menin-MLL inhibitor 3;MI-3 (Menin-MLL Inhibitor);MI-3 (Menin-MLL Inhibitor) USP/EP/BP;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl);MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor;4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine
- 中文名:
- MI-3 (Menin-MLL Inhibitor)
- 中文別名:
- 化合物MI-3;化合物MI-3,10 MM DMSO 溶液;MI-3,MENIN-MLL 相互作用抑制劑;MI-3(MENIN-MLL INHIBITOR 3);4-(4-(5,5-二甲基-4,5-二氫噻唑-2-基)哌嗪-1-基)-6-異丙基噻吩并[2,3-D]嘧啶;4-[4-(4,5-二氫-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-異丙基噻吩并[2,3-D]嘧啶
- CBNumber:
- CB42624233
- 分子式:
- C18H25N5S2
- 分子量:
- 375.55
- MOL File:
- 1271738-59-0.mol
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MI-3 (Menin-MLL Inhibitor)化學性質
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沸點:
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527.9±60.0 °C(Predicted)
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密度:
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1.36±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)
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形態(tài):
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Powder
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酸度系數(shù)(pKa):
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9.59±0.40(Predicted)
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顏色:
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Light yellow to yellow
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MI-3 (Menin-MLL Inhibitor)性質、用途與生產工藝
MI-3 (Menin-MLL抑制劑)可抑制白血病中MLL融合蛋白的致癌活性。
MI-3 (Menin-MLL Inhibitor)是一種強效的menin-MLL相互作用抑制劑，IC50為 648 nM。
在HEK293細胞中，MI-3接近蛋白質靶點，并有效抑制menin-MLL-AF9相互作用。MI-3通過下調MLL融合蛋白致癌活性所需的靶點基因的表達，有效阻斷MLL融合蛋白介導的白血病轉化。在攜帶不同MLL易位的人MLL白血病細胞系，MI-3有效阻斷細胞分化，并誘導細胞凋亡。
IC50: 648 nM (menin-MLL); Kd: 201 nM (menin-MLL)
MI-3 (Menin-MLL Inhibitor)
上下游產品信息
上游原料
下游產品
| 更新日期 | 產品編號 | 產品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/02/08 | HY-15223 | MI-3 (Menin-MLL Inhibitor)
MI-3 | 1271738-59-0 | 5mg | 1194元 |
| 2025/02/08 | HY-15223 | MI-3 (Menin-MLL Inhibitor)
MI-3 | 1271738-59-0 | 10mM * 1mLin DMSO | 1313元 |
MI-3 (Menin-MLL Inhibitor)
生產廠家
1271738-59-0, MI-3 (Menin-MLL Inhibitor) 相關搜索:
- Inhibitors
- 抑制劑
- 合成有機化合物配體
- 活性小分子庫
- 小分子抑制劑，天然產物
- 小分子抑制劑
- 化合物MI-3,10 MM DMSO 溶液
- 4-(4-(5,5-二甲基-4,5-二氫噻唑-2-基)哌嗪-1-基)-6-異丙基噻吩并[2,3-D]嘧啶
- MI-3,MENIN-MLL 相互作用抑制劑
- 化合物MI-3
- MI-3(MENIN-MLL INHIBITOR 3)
- 4-[4-(4,5-二氫-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-異丙基噻吩并[2,3-D]嘧啶
- 1271738-59-0
- MI-3, 10 mM in DMSO
- 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine
- MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor
- MI-3 (Menin-MLL Inhibitor) USP/EP/BP
- CS-1809
- MI3;MI 3;MENIN-MLL INHIBITOR 3;THIENO[2;3-D]PYRIMIDINE; 4-[4-(4;5-DIHYDRO-5;5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL)
- 5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)
- 5-dihydro-5
- 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3
- MI-3 (Menin-MLL Inhibitor)
- 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine
- Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
- Menin-MLL inhibitor 3
- MI-3