ML 145
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- CAS號:
- 1164500-72-4
- 英文名:
- ML 145
- 英文別名:
- ML 145;2-Hydroxy-4-(4-((Z)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanamido)benzoic acid;2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid;Benzoic acid, 2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]-
- 中文名:
- ML 145
- 中文別名:
- 化合物 ML 145;化合物 T12074;2-羥基-4-(4-((Z)-5-((E)-2-甲基-3-苯基亞烯丙基)-4-氧代-2-硫代噻唑烷-3-基)丁酰氨基)苯甲酸
- CBNumber:
- CB42535683
- 分子式:
- C24H22N2O5S2
- 分子量:
- 482.57188
- MOL File:
- 1164500-72-4.mol
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ML 145化學(xué)性質(zhì)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble to 100 mM in DMSO
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形態(tài):
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Powder
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顏色:
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Yellow to brown
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InChIKey:
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COFMYJWNXSFLKQ-QIROLCGISA-N
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SMILES:
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C(O)(=O)C1=CC=C(NC(=O)CCCN2C(=O)/C(=C/C(/C)=C/C3=CC=CC=C3)/SC2=S)C=C1O
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ML 145性質(zhì)、用途與生產(chǎn)工藝
ML 145 是選擇性，競爭性的人 GPR35/CXCR8 拮抗劑，IC50/EC50 為 20.1 nM。ML 145 對 GPR35 的選擇性比 GPR55 (IC50/EC50=21.7 μM) 高超 1000 倍。 ML 145 對嚙齒動物直系同源物的 GPR35 均無明顯活性。
IC50/EC50: 20.1 nM (GPR35), 21.7 μM (GPR55)
ML 145 (10 μM) also fully blocks internalization of human FLAG-GPR35-eYFP in response to varying concentrations of Zaprinast, Cromolyn disodium, and Pamoate.
ML 145 is either without effect (mouse) or displays only a small and apparently noncompetitive inhibitory effect (rat) at the rodent orthologs.
ML 145 acts as a competitive antagonist for a number of agonists at human GPR35 and has an IC
50
value against EC
80
concentrations of various GPR35 agonists in the region of 20 nM.
ML 145
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上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/05/22 | HY-107536 | ML 145
ML 145 | 1164500-72-4 | 5mg | 1200元 |
| 2025/05/22 | HY-107536 | ML 145
ML 145 | 1164500-72-4 | 10mM * 1mLin DMSO | 1320元 |
1164500-72-4, ML 145 相關(guān)搜索:
- 化學(xué)試劑
- 抑制劑
- 2-羥基-4-(4-((Z)-5-((E)-2-甲基-3-苯基亞烯丙基)-4-氧代-2-硫代噻唑烷-3-基)丁酰氨基)苯甲酸
- 化合物 ML 145
- 化合物 T12074
- 1164500-72-4
- 2-Hydroxy-4-(4-((Z)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanamido)benzoic acid
- Benzoic acid, 2-hydroxy-4-[[4-[(5Z)-5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxobutyl]amino]-
- 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
- ML 145