鹽酸頭孢唑蘭
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- CAS號(hào):
- 113981-44-5
- 英文名:
- Cefozopran hydrochloride
- 英文別名:
- Czop;D02233;Firstcin (tn);Cefozopran hydrochlo;Cefozopran Impurity 1;SCE-2787 hydrochloride;Cefozopran hydrochloride;Cefozopran hydrochloride (jp15);Cefozopran hydrochloride USP/EP/BP;1-(((6R,7R)-7-((Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)imidazo[1,2-b]pyridazin-1-ium chloride
- 中文名:
- 鹽酸頭孢唑蘭
- 中文別名:
- 鹽酸頭孢唑蘭;頭孢唑蘭鹽酸鹽;CEFOZOPAN單鹽酸甲氯化物;PERFEMIKER]鹽酸頭孢唑蘭,97%;1-[[(6R,7R)-7-[(Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-甲氧亞氨基乙酰胺基]-2-羧基-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-3-基]甲基]咪唑并[1,2-B]噠嗪內(nèi)鹽鹽酸鹽;1-[[(6R,7R)-7-[(Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-甲氧亞氨基乙酰胺基]-2-羧基-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-3-基]甲基]咪唑并[1,2-b]噠嗪鎓內(nèi)鹽鹽酸鹽;1-(((6R,7R)-7-((Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-(甲氧基亞氨基)乙酰胺基)-2-羧基-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-3-基)甲基)咪唑[1,2-B]噠嗪-1-氯化銨
- CBNumber:
- CB41074592
- 分子式:
- C19H18ClN9O5S2
- 分子量:
- 551.98
- MOL File:
- 113981-44-5.mol
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鹽酸頭孢唑蘭化學(xué)性質(zhì)
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儲(chǔ)存條件:
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under inert gas (nitrogen or Argon) at 2-8°C
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形態(tài):
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Solid
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顏色:
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White to light yellow
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水溶解性:
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Water : ≥ 52 mg/mL (94.20 mM)
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鹽酸頭孢唑蘭性質(zhì)、用途與生產(chǎn)工藝
鹽酸頭孢唑蘭(cefozopran hydrochloride)是日本武田藥品工業(yè)公司研發(fā)的第四代注射用頭孢菌素，目前在日本已作為院外感染初期的首選藥物被廣泛應(yīng)用于包括新生兒感染在內(nèi)的各科感染癥的治療。除了MRSA外，它具有廣譜活性，對(duì)革蘭陽(yáng)性菌的活性總體上優(yōu)于頭孢他啶、頭孢毗肟和氟氧頭孢，而與頭孢匹羅相當(dāng)，對(duì)革蘭陰性菌與上述對(duì)照藥具有同等的活性。它對(duì)β?內(nèi)酰胺酶有高度的穩(wěn)定性，體內(nèi)分布廣泛，血漿和組織濃度較高，大部分以原藥形式從尿中排泄．24h尿排泄率80%～90%，無(wú)體內(nèi)蓄積傾向。鹽酸頭孢唑蘭的化學(xué)名稱(chēng)為：[[(6R,7R)-7-[(Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-甲氧亞氨基乙酰氨基]-2-羧基-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-3-基]甲基]咪唑并[1,2-b]噠嗪鎓氫氧化物內(nèi)鹽單鹽酸鹽。
Cefozopran (SCE-2787) hydrochloride 是一種半合成的、非腸道的、第四代頭孢菌素。Cefozopran hydrochloride，作為一種抗生素，具有廣譜抗菌活性，能抑制大多數(shù)革蘭氏陰性和革蘭氏陽(yáng)性菌。
Cefozopran (SCE-2787) is a fourth-generation cephalosporin that has good activity against gram-positive organisms including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci; and against gram-negative organisms including hemophilus influenza. Moreover, cefozopran has comparatively good activity against enterococci and
P. aeruginosa
, which are refractory to other cephalosporins.
Cefozopran (SCE-2787) (5-80 mg/kg; s.c.; twice a day for 5 days; four-week-old ICR male mice) is effective against acute respiratory tract infections caused by
Kiebsiella pneumonia
DT-S. In the model of chronic respiratory tract infection caused by
K. pneumoniae
27, Cefozopran (20-80 mg/kg; s.c.; twice a day for 7 days; five-week-old CBA/J female mice) is as effective as Ceftazidime.
用途
抗感染
用途
鹽酸頭孢唑蘭適用于葡萄球菌、鏈球菌、腸球菌、消化鏈球菌、大腸桿菌、腸桿菌、沙雷氏菌、克雷白氏菌、枸櫞酸桿菌、變形桿菌、假單孢菌、流感桿菌、不動(dòng)桿菌、擬桿菌中對(duì)鹽酸頭孢唑蘭敏感菌引起的敗血癥，外傷感染，呼吸系統(tǒng)、泌尿系統(tǒng)及腹腔、盆腔內(nèi)化膿性炎癥，眼科和耳鼻喉科炎癥等。
鹽酸頭孢唑蘭
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/05/22 | HY-B0771A | 鹽酸頭孢唑蘭
Cefozopran hydrochloride | 113981-44-5 | 5 mg | 562元 |
| 2025/05/22 | HY-B0771A | 鹽酸頭孢唑蘭
Cefozopran hydrochloride | 113981-44-5 | 10 mg | 650元 |
113981-44-5, 鹽酸頭孢唑蘭 相關(guān)搜索:
- Cefozopran Hydrochloride and its intermediates
- 抑制劑
- 藥靶配體
- 醫(yī)藥、農(nóng)藥及染料中間體
- 藥物雜質(zhì)及中間體
- 醫(yī)藥原料藥
- 鹽酸頭孢唑蘭及其中間體
- C19H17N9O5S2HCl
- CEFOZOPAN單鹽酸甲氯化物
- PERFEMIKER]鹽酸頭孢唑蘭,97%
- 1-(((6R,7R)-7-((Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-(甲氧基亞氨基)乙酰胺基)-2-羧基-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-3-基)甲基)咪唑[1,2-B]噠嗪-1-氯化銨
- 1-[[(6R,7R)-7-[(Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-甲氧亞氨基乙酰胺基]-2-羧基-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-3-基]甲基]咪唑并[1,2-B]噠嗪內(nèi)鹽鹽酸鹽
- 1-[[(6R,7R)-7-[(Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-甲氧亞氨基乙酰胺基]-2-羧基-8-氧代-5-硫雜-1-氮雜雙環(huán)[4.2.0]辛-2-烯-3-基]甲基]咪唑并[1,2-b]噠嗪鎓內(nèi)鹽鹽酸鹽
- 頭孢唑蘭鹽酸鹽
- 鹽酸頭孢唑蘭
- 113981-44-5
- Cefozopran Impurity 1
- 1-(((6R,7R)-7-((Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)imidazo[1,2-b]pyridazin-1-ium chloride
- Cefozopran hydrochloride USP/EP/BP
- SCE-2787 hydrochloride
- Cefozopran hydrochlo
- Firstcin (tn)
- D02233
- Czop
- Cefozopran hydrochloride (jp15)
- (6R,7R)-7-[[(2E)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl]amino]-3-(imidazo[2,3-f]pyridazin-4-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid chloride
- Cefozopran hydrochloride