3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮
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- CAS號:
- 415713-60-9
- 英文名:
- RI-1
- 英文別名:
- RI-1;CS-909;RI1;RI-1;RI-1, >=98%;RAD51 inhibitor;RI-1 >=98% (HPLC);RAD51 inhibitor 1;RI-1, 10 mM in DMSO;RAD51 inhibitor RI-1;RI 1, RAD51 inhibitor
- 中文名:
- 3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮
- 中文別名:
- 化合物RI1;13-氯-1-(3;人卵巢腺癌細胞EFO27;人B細胞淋巴瘤 RI-1;RI-1,RAD51抑制劑;RAD51抑制劑(RI-1);化合物RI1,10 MM DMSO 溶液;4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2;3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮
- CBNumber:
- CB32628355
- 分子式:
- C14H11Cl3N2O3
- 分子量:
- 361.61
- MOL File:
- 415713-60-9.mol
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3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮化學性質
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沸點:
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483.0±45.0 °C(Predicted)
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密度:
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1.61
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儲存條件:
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2-8°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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酸度系數(pKa):
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-3.45±0.20(Predicted)
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形態(tài):
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powder
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顏色:
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yellow to orange
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生物來源:
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human blood
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穩(wěn)定性:
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Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮性質、用途與生產工藝
人源(Homo sapiens)
外周血(Peripheral blood)
懸浮生長(Suspension)
57歲(57 years)
淋巴母細胞(Lymphoblastoid)
彌漫性大 B 細胞淋巴瘤(Diffuse large B-cell lymphoma)
RI-1 (RAD51 inhibitor 1)是RAD51抑制劑,IC50為5至30 μM。
RI-1通過直接和特異破壞HsRAD51和抑制RAD51,形成對單鏈DNA細絲的能力,提高細胞對DNA損傷的敏感性。此外,在所有三種癌細胞株(HeLa細胞,MCF-7和U2OS)中,RI-1單獨產生單劑毒性,LD50值在20-40微米范圍內。 RI-1減少了在G2期細胞的γ-H2AX灶,并導致在輻射6小時后未修復DNA雙鏈斷裂的升高。
RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice.
Animal Model:
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Female BALB/c nude mice (6 weeks) bearing TNBC tumor
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Dosage:
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50 mg/kg
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Administration:
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I.p. every 3 days for 30 days
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Result:
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Resulted in significant inhibition of tumor growth.
Did not cause body weight loss significantly.
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3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮
上下游產品信息
上游原料
下游產品
更新日期 | 產品編號 | 產品名稱 | CAS編號 | 包裝 | 價格 |
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2025/05/22 | HY-15317 | 3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮 RI-1 | 415713-60-9 | 5 mg | 750元 |
2025/05/22 | S8077 | 3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮 RI-1 | 415713-60-9 | 10mg | 1626.33元 |
3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮
生產廠家
415713-60-9, 3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮 相關搜索:
- Inhibitors
- ATCC細胞-ATCC細胞系
- 抑制劑
- 細胞-細胞系
- 細胞系
- 藥靶配體
- 細胞生物學試劑
- 小分子抑制劑,天然產物
- 小分子抑制劑
- 化合物RI1,10 MM DMSO 溶液
- 人卵巢腺癌細胞EFO27
- 人B細胞淋巴瘤 RI-1
- RI-1,RAD51抑制劑
- 化合物RI1
- 4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2
- 13-氯-1-(3
- RAD51抑制劑(RI-1)
- 3-氯-1-(3,4-二氯苯基)-4-(4-嗎啉基)-1H-吡咯-2,5-二酮
- 415713-60-9
- RI-1, 10 mM in DMSO
- RI 1, RAD51 inhibitor
- recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit
- RI1;RI-1
- 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
- CS-909
- 3-chloro-1-(3,4-dichlorophenyl)-4-(morpholin-4-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
- RAD51 inhibitor
- RI-1 >=98% (HPLC)
- 1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-
- 3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
- RAD51 inhibitor 1
- RAD51 inhibitor RI-1
- RI-1, >=98%
- 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
- RI-1