達(dá)巴萬(wàn)星鹽酸鹽
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- CAS號(hào):
- 2227366-51-8
- 英文名:
- Dalbavancin hydrochloride
- 英文別名:
- BI-397 hydrochloride;MDL-63397 hydrochloride;Dalbavancin Hydrochloride(Mixture)
- 中文名:
- 達(dá)巴萬(wàn)星鹽酸鹽
- 中文別名:
- 鹽酸道古霉素;鹽酸達(dá)巴萬(wàn)星;達(dá)巴萬(wàn)星鹽酸鹽;鹽酸達(dá)巴萬(wàn)星(混合物);化合物 DALBAVANCIN HYDROCHLORIDE
- CBNumber:
- CB28029346
- 分子式:
- C88H101Cl3N10O28
- 分子量:
- 1853.17
- MOL File:
- 2227366-51-8.mol
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達(dá)巴萬(wàn)星鹽酸鹽化學(xué)性質(zhì)
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儲(chǔ)存條件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO: ≥ 24 mg/mL (12.95 mM)
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形態(tài):
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Solid
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顏色:
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White to light yellow
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水溶解性:
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Water: 50 mg/mL (26.98 mM)
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達(dá)巴萬(wàn)星鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
Dalbavancin hydrochloride(MDL-63397 hydrochloride) 是一種半合成的脂糖肽抗生素，對(duì)革蘭氏陽(yáng)性細(xì)菌具有有效的殺菌活性。Dalbavancin hydrochloride 抑制金黃色葡萄球菌和炭疽芽孢桿菌的 MIC90 分別為 0.06 μg/mL 和 0.25 μg/mL。
Dalbavancin is a parenterally administered semisynthetic lipoglycopeptide developed to combat infections caused by resistant gram-positive pathogens. Dalbavancin exhibits potent in vitro bactericidal activity against gram-positive pathogens including
S. aureus
(MRSA), VISA, and non-VanA strains of VRE. Dalbavancin is developed for the treatment of complicated skin and skin structure infections (cSSSIs), predominantly those caused by MRSA and
β-hemolytic streptococci
, organisms against which it has shown greater potency than existing glycopeptide therapeutic agents.
Dalbavancin (15-240 mg/kg; intraperitoneal injection; every 36 h or 72 h; for 14 days; female BALB/c mice) treatment has a survival rate of 80% to 100% of mice with all dose regimens.
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Animal Model:
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Female BALB/c mice (6-8 weeks) challenged with Ames strain of
B. anthracis
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Dosage:
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15 mg/kg, 30 mg/kg, 60 mg/kg, 120 mg/kg, 240 mg/kg
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Administration:
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Intraperitoneal injection; every 36 h or 72 h; for 14 days
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Result:
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The efficacy was 80 to 100%, as determined by the rate of survival at 42 days, when treatment was initiated 24 h postchallenge with regimens of 15 to 120 mg/kg every 36 h or 30 to 240 mg/kg every 72 h.
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達(dá)巴萬(wàn)星鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
達(dá)巴萬(wàn)星鹽酸鹽
生產(chǎn)廠家
2227366-51-8, 達(dá)巴萬(wàn)星鹽酸鹽 相關(guān)搜索:
- 雜質(zhì)對(duì)照品
- 抑制劑
- 生化試劑
- 化學(xué)試劑
- 化工中間體
- 現(xiàn)貨
- 精細(xì)化工原料
- 原料藥
- 醫(yī)藥原料
- 鹽酸達(dá)巴萬(wàn)星(混合物)
- 化合物 DALBAVANCIN HYDROCHLORIDE
- 鹽酸達(dá)巴萬(wàn)星
- 達(dá)巴萬(wàn)星鹽酸鹽
- 鹽酸道古霉素
- 2227366-51-8
- Dalbavancin Hydrochloride(Mixture)
- MDL-63397 hydrochloride
- BI-397 hydrochloride