(S)-(-)-卡維地洛
|
|
|
- CAS號(hào):
- 95094-00-1
- 英文名:
- (S)-(-)-CARVEDILOL
- 英文別名:
- (S)-BM 14190;(S)-(-)-CARVEDILOL;Carvedilol S-IsoMer;Carvedilol Impurity 11;(S)Carvedilol,(S) Carvedilol;Carvedilol Impurity 11（(S) Isomer）;(2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;(-)-1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL;(S)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol;(2S)-1-(9H-Carbazole-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propane-2-ol
- 中文名:
- (S)-(-)-卡維地洛
- 中文別名:
- S-卡維地絡(luò);(S)-卡維地洛;卡維地洛S-異構(gòu)體;化合物 T12794;卡維地洛雜質(zhì)11(S異構(gòu)體)
- CBNumber:
- CB2190419
- 分子式:
- C24H26N2O4
- 分子量:
- 406.47
- MOL File:
- 95094-00-1.mol
|
|
|
(S)-(-)-卡維地洛化學(xué)性質(zhì)
-
熔點(diǎn):
-
114-115°C
-
|
-
沸點(diǎn):
-
655.2±55.0 °C(Predicted)
-
|
-
密度:
-
1.250±0.06 g/cm3(Predicted)
-
|
-
儲(chǔ)存條件:
-
-20°C Freezer
-
|
-
溶解度:
-
Acetic Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
-
|
-
形態(tài):
-
Solid
-
|
-
酸度系數(shù)(pKa):
-
13.90±0.20(Predicted)
-
|
-
顏色:
-
White to Off-White
-
|
-
穩(wěn)定性:
-
Hygroscopic
-
|
(S)-(-)-卡維地洛性質(zhì)、用途與生產(chǎn)工藝
(S)-Carvedilol 是 Carvedilol 的 S 型異構(gòu)體，是一種非選擇性 β/α-1 受體阻斷劑。(S)-Carvedilol 可以抵抗 Doxorubicin (DOX) 的血管或心臟毒性。
β/α-1 adrenergic receptor
The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers.
(S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro.
(S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs.
用途
The optically active isomer of Carvedilol (C184625), a nonselective β-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.
(S)-(-)-卡維地洛
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-B0006B | (S)-(-)-卡維地洛
(S)-Carvedilol | 95094-00-1 | 5mg | 1100元 |
| 2024/11/08 | HY-B0006B | (S)-(-)-卡維地洛
(S)-Carvedilol | 95094-00-1 | 10mg | 1800元 |
95094-00-1, (S)-(-)-卡維地洛 相關(guān)搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Chiral Reagents
- Heterocycles
- Aromatics
- API
- 抑制劑
- 雜質(zhì)
- 卡維地洛雜質(zhì)11(S異構(gòu)體)
- 化合物 T12794
- S-卡維地絡(luò)
- (S)-卡維地洛
- 卡維地洛S-異構(gòu)體
- 95094-00-1
- (S)Carvedilol,(S) Carvedilol
- Carvedilol Impurity 11
- (S)-BM 14190
- (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
- Carvedilol Impurity 11（(S) Isomer）
- (S)-(-)-CarvedilolQ: What is
(S)-(-)-Carvedilol Q: What is the CAS Number of
(S)-(-)-Carvedilol Q: What is the storage condition of
(S)-(-)-Carvedilol Q: What are the applications of
(S)-(-)-Carvedilol
- [S,(-)]-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
- (S)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
- (2S)-1-(9H-Carbazole-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propane-2-ol
- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (S)-
- 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-, (2S)-
- (S)-(-)-CARVEDILOL
- Carvedilol S-IsoMer
- (-)-1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL