N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
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- CAS號:
- 314054-00-7
- 英文名:
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
- 英文別名:
- C-176;STING inhibitor 1;C-176, 10 mM in DMSO;C-176 STING inhibitor;N-(4-iodophenyl)-5-nitro-2-furamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
- 中文名:
- N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
- 中文別名:
- 化合物C-176;STING抑制劑,C-176;C-176, STING 抑制劑;化合物C-176,10 MM DMSO 溶液;N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺;N-(4-碘苯基)-5-硝基-2-呋喃甲酰胺
- CBNumber:
- CB04522191
- 分子式:
- C11H7IN2O4
- 分子量:
- 358.09
- MOL File:
- 314054-00-7.mol
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N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺化學(xué)性質(zhì)
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沸點:
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361.2±37.0 °C(Predicted)
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密度:
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1.935±0.06 g/cm3(Predicted)
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儲存條件:
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2-8°C(protect from light)
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溶解度:
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Soluble in DMSO (up to 25 mg/ml)
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酸度系數(shù)(pKa):
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11.14±0.70(Predicted)
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形態(tài):
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solid
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顏色:
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Brown or yellow
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穩(wěn)定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺性質(zhì)、用途與生產(chǎn)工藝
STING inhibitor C-176是一種有效的STING抑制劑。STING是細胞內(nèi)DNA感應(yīng)通路的主要信號分子。
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.
C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1
?/?
mice.
C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1
?/?
mice.
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Animal Model:
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WT type mice.
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Dosage:
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750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
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Administration:
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Intraperitoneally, once.
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Result:
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Significantly reduced Serum levels of type I IFNs and IL-6.
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N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2025/02/08 | HY-112906 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
C-176 | 314054-00-7 | 5mg | 1000元 |
| 2025/02/08 | HY-112906 | N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
C-176 | 314054-00-7 | 10mM * 1mLin DMSO | 1100元 |
N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
生產(chǎn)廠家
314054-00-7, N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺 相關(guān)搜索:
- 化學(xué)試劑
- 抑制劑
- 藥靶配體
- 化合物C-176,10 MM DMSO 溶液
- STING抑制劑,C-176
- C-176, STING 抑制劑
- N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
- 化合物C-176
- N-(4-碘苯基)-5-硝基-2-呋喃甲酰胺
- 314054-00-7
- C-176, 10 mM in DMSO
- STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
- N-(4-iodophenyl)-5-nitro-2-furamide
- 2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-
- STING inhibitor 1
- C-176 STING inhibitor
- C-176
- N-(4-iodophenyl)-5-nitrofuran-2-carboxamide