MK-2 INHIBITOR III (COMPOUND 16)
|
|
|
- CAS號(hào):
- 1186648-22-5
- 英文名:
- MK-2 Inhibitor III
- 英文別名:
- MK2-IN-3 hydrate;MK-2 Inhibitor III;MK2-IN-3 hydrate, 10 mM in DMSO;MK-2 INHIBITOR III (COMPOUND 16);MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem;2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate;2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate;Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
- 中文名:
- MK-2 INHIBITOR III (COMPOUND 16)
- 中文別名:
- 化合物MK-2 INHIBITOR III;MK-2 INHIBITOR III H2O;化合物MK-2 INHIBITOR III,10 MM DMSO 溶液;2-(2-(喹啉-3-基)吡啶-4-基)-6,7-二氫-1H-吡咯并[3,2-C]吡啶-4(5H)-酮水合物
- CBNumber:
- CB03136757
- 分子式:
- C21H18N4O2
- 分子量:
- 358.4
- MOL File:
- 1186648-22-5.mol
|
|
|
MK-2 INHIBITOR III (COMPOUND 16)化學(xué)性質(zhì)
-
熔點(diǎn):
-
>255°C (dec.)
-
|
-
儲(chǔ)存條件:
-
+2C to +8C
-
|
-
溶解度:
-
DMSO (Slightly), Methanol (Slightly)
-
|
-
形態(tài):
-
Pale yellow solid
-
|
-
顏色:
-
Off-White to Pale Yellow
-
|
MK-2 INHIBITOR III (COMPOUND 16)性質(zhì)、用途與生產(chǎn)工藝
MK2-IN-3 hydrate (compound 16) 是一種具有口服活性的，選擇性的，ATP 競(jìng)爭(zhēng)性的 MAPKAP-K2 (MK-2) 抑制劑，IC50 值為 0.85 nM。MK2-IN-3 hydrate 對(duì) MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1(IC50=5.7 μM) 以及 CDK2, JNK2, IKK2, MSK1, and MSK2 也具有選擇性。
IC50: 0.85 nM (MK-2), 0.21 μM (MK-3), 0.081 μM (MK-5), 3.44 μM (ERK2), 5.7 μM (MNK1)
MK2-IN-3 hydrate suppresses TNFα production in U397 cells with an IC
50
of 4.4 μM.
MK-2 INHIBITOR III (COMPOUND 16)
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/02/08 | HY-112457 | MK-2 INHIBITOR III (COMPOUND 16)
MK2-IN-3 hydrate | 1186648-22-5 | 1 mg | 923元 |
| 2025/02/08 | HY-112457 | MK-2 INHIBITOR III (COMPOUND 16)
MK2-IN-3 hydrate | 1186648-22-5 | 10 mM * 1 mLin DMSO | 1410元 |
MK-2 INHIBITOR III (COMPOUND 16)
生產(chǎn)廠家
1186648-22-5, MK-2 INHIBITOR III (COMPOUND 16) 相關(guān)搜索:
- 抑制劑
- 化合物MK-2 INHIBITOR III,10 MM DMSO 溶液
- 2-(2-(喹啉-3-基)吡啶-4-基)-6,7-二氫-1H-吡咯并[3,2-C]吡啶-4(5H)-酮水合物
- 化合物MK-2 INHIBITOR III
- MK-2 INHIBITOR III H2O
- 1186648-22-5
- MK2-IN-3 hydrate, 10 mM in DMSO
- Inhibitor,MAP kinase activated protein kinase 2,inhibit,MK2 IN 3 hydrate,MAPKAP kinase 2,MK-2-IN-3 hydrate,MAPK activated protein kinase 2,MK2IN3 hydrate,MAPKAPK2 (MK2),Mitogen-activated protein kinase activated protein kinase 2
- 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrate
- MK2-IN-3 hydrate
- MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem
- MK-2 INHIBITOR III (COMPOUND 16)
- 2-(2-quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one:hydrate
- MK-2 Inhibitor III