SIB 1553A hydrochloride
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- CAS號:
- 191611-89-9
- 英文名:
- SIB 1553A hydrochloride
- 英文別名:
- SIB 1553A,SIB1553A;SIB 1553A hydrochloride;SIB 1553A Hyrdrochloride;SIB 1553A hydrochloride, nAChR agonist;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol:hydrochloride;(±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
- 中文名:
- SIB 1553A hydrochloride
- 中文別名:
- 化合物 T16881;SIB-1553A 鹽酸鹽;SIB 1553A HYDROCHLORIDE,NACHR激動劑
- CBNumber:
- CB03037533
- 分子式:
- C13H20ClNOS
- 分子量:
- 273.82
- MOL File:
- 191611-89-9.mol
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SIB 1553A hydrochloride化學性質
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熔點:
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149-151°C
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儲存條件:
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Hygroscopic, Refrigerator, under inert atmosphere
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溶解度:
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DMSO (Slightly), Water (Slightly)
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形態(tài):
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Solid
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顏色:
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White to Off-White
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水溶解性:
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Soluble to 100 mM in water
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SIB 1553A hydrochloride性質、用途與生產(chǎn)工藝
SIB-1553A 是一種口服生物有效的煙堿乙酰膽堿受體 (nAChRs) 激動劑，對含有 nAChRs 的 β4 亞單位具有選擇性。SIB-1553A 也是一種選擇性配體神經(jīng)元 nAChR 配體。SIB-1553A 是一種認知增強劑，對阿爾茨海默病和其他認知障礙的癥狀研究具有潛在的研究潛力。
SIB-1553A displaces the binding of
[H]
nicotine (NIC) to the rat brain nAChRs with an IC
50
value of 110 nM.
In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency.
SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels.
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Animal Model:
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Male Sprague-Dawley rats (200-250 g)
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Dosage:
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1, 2, 4, 10, 20 and 40 mg/kg
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Administration:
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s.c.
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Result:
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Induced hippocampal ACh release.
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SIB 1553A hydrochloride
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
SIB 1553A hydrochloride
生產(chǎn)廠家
191611-89-9, SIB 1553A hydrochloride 相關搜索:
- 抑制劑
- C13H19NOSHCl
- SIB 1553A HYDROCHLORIDE,NACHR激動劑
- SIB-1553A 鹽酸鹽
- 化合物 T16881
- 191611-89-9
- SIB 1553A hydrochloride, nAChR agonist
- SIB 1553A,SIB1553A
- 4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol:hydrochloride
- SIB 1553A Hyrdrochloride
- (±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
- 4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol
- SIB 1553A hydrochloride