99489-94-8
中文名稱(chēng)
RELAXIN H2 (HUMAN)
英文名稱(chēng)
Relaxin H2 (human)
CAS
99489-94-8
分子式
C256H408N74O74S8
分子量
5962.95
MOL 文件
99489-94-8.mol
99489-94-8 結(jié)構(gòu)式
基本信息
英文別名
Relaxin H2 (human)PubChem ID: 71300755
Relaxin H2 (human) trifluoroacetate salt
(Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B
(Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-IleLys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B(Cys10A&Cys15ABridge,Cys11A&Cys1
(Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-IleLys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B(Cys10A&Cys15ABridge,Cys11A&Cys11BBridge,Cys24A&Cys23BBridge)(Relax in H2 Human)
常見(jiàn)問(wèn)題列表
生物活性
Serelaxin (RLX-030) 是一種靶向 RLN 受體 的重組人松弛素，是一種具有抗纖維化活性的血管活性肽激素。體內(nèi)研究
Serelaxin (0.5 mg/kg per day, subcutaneous administration) produces 20 to 40 ng/mL of circulating hormone, which successfully prevents and reduces fibrosis progression in various experimental models of injury. The doses do not exhibit significant toxicity.
Serelaxin restores endothelial function by increasing nitric oxide (NO)-mediated relaxation but not endothelium-derived hyperpolarisation (EDH).
| Animal Model: | Six- to 8-week-old male mice (on a 129sv or 129sv×C57B6J background, which were equally sensitive to tissue injury and fibrosis). |
| Dosage: | 0.5 mg/kg. |
| Administration: | Subcutaneous administration per day for 7 days. |
| Result: | Produced 20 to 40 ng/mL of circulating hormone. |