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96192-35-7

中文名稱 Ε-N-脫氧果糖賴氨酸二鹽酸鹽
英文名稱 ε-N-Deoxyfructosyllysine dihydrochloride
CAS 96192-35-7
分子式 C12H25ClN2O7
分子量 344.79
MOL 文件 96192-35-7.mol
96192-35-7 結(jié)構(gòu)式 96192-35-7 結(jié)構(gòu)式

基本信息

中文別名
Ε-N-脫氧果糖賴氨酸二鹽酸鹽
英文別名
Fructosyl-lysine dihydrochloride

物理化學(xué)性質(zhì)

儲存條件4°C, protect from light, stored under nitrogen
形態(tài)Solid
顏色Brown to black

常見問題列表

生物活性
Fructosyl-lysine (Fructoselysine) dihydrochloride 是葡萄糖與賴氨酸通過美拉德反應(yīng)生成的一種氨基糖基化產(chǎn)物 (amadori glycation)。Fructosyl-lysine 是葡萄糖烷的前體,葡萄糖烷是一種賴氨酸-精氨酸蛋白交聯(lián)物,可作為糖尿病中檢測的指標。
靶點

IC50: precursor to glucosepane

體外研究

Fructosyl-lysine dihydrochloride (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [ 14 C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E?.coli extracts.Fructosyl-lysine dihydrochloride (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E?.coli extracts.Fructosyl-lysine dihydrochloride (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose.

體內(nèi)研究

Fructosyl-lysine dihydrochloride and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats.

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