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945725-50-8

英文名稱 TASP 0277308
CAS 945725-50-8
分子式 C23H28Cl2N6O3S
分子量 539.48
MOL 文件 945725-50-8.mol
945725-50-8 結構式 945725-50-8 結構式

基本信息

英文別名
TASP 0277308
3,4-dichloro-N-[(1R)-1-[4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-1,2,4-triazol-3-yl]ethyl]benzenesulfonamide
3,4-dichloro-N-[(1R)-1-{4-ethyl-5-[3-(4-methylpiperazin-1-yl)phenoxy]-4H-1,2,4-triazol-3-yl}ethyl]benzenesulfonamide

物理化學性質

溶解度Soluble to 5 mM in DMSO

應用領域

用途一
TASP0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP0277308 inhibited S1P- as well as VEGF-induced cellular responses, including migration and proliferation of human umbilical vein endothelial cells. Furthermore, TASP0277308 effectively blocked a VEGF-induced tube formation in vitro and significantly suppressed tumor cell-induced angiogenesis in vivo.
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