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945526-43-2

中文名稱 STEM-CELL FACTOR/C-KIT 抑制劑
英文名稱 [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
CAS 945526-43-2
分子式 C19H21N3O2S
分子量 355.45
MOL 文件 945526-43-2.mol
更新日期 2024/12/16 10:21:49
945526-43-2 結(jié)構(gòu)式 945526-43-2 結(jié)構(gòu)式

基本信息

中文別名
化合物ISCK03
STEM-CELL FACTOR/C-KIT 抑制劑
英文別名
ISCK03
ISCK 03
ISCK-03
C-KIT INHIBITOR II
Stem-Cell Factor/c-Kit Inhibitor
SteM-Cell Factor/c-Kit Inhibitor, ISCK03
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]
Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

物理化學(xué)性質(zhì)

儲(chǔ)存條件Sealed in dry,2-8°C
溶解度溶于乙醇或DMSO
形態(tài)固體
顏色黃色
敏感性感光
InChIKeyXQABBHBFHWHMKF-UHFFFAOYSA-N

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36
安全說(shuō)明26
WGK Germany1
STEM-CELL FACTOR/C-KIT 抑制劑 價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-101443STEM-CELL FACTOR/C-KIT 抑制劑
ISCK03
945526-43-25mg600元
2024/11/08HY-101443STEM-CELL FACTOR/C-KIT 抑制劑
ISCK03
945526-43-210mM * 1mLin DMSO660元
2024/11/08HY-101443STEM-CELL FACTOR/C-KIT 抑制劑
ISCK03
945526-43-210mg1000元

常見(jiàn)問(wèn)題列表

生物活性
ISCK03 (N-(4-imidazol-1-yl phenyl)sulfonamide)是stem-cell factor (SCF)/c-kit信號(hào)通路的細(xì)胞滲透性抑制劑。ISCK03抑制SCF介導(dǎo)的c-c-kit磷酸化和下游ERK磷酸化。
靶點(diǎn)
TargetValue
SCF
()
c-Kit
()
體外研究

Pretreatment of 501mel cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. However ISCK03 does not inhibit hepatocyte growth factor (HGF)-induced phosphorylation of p44/42 ERK proteins. ISCK03, a tyrosine kinase inhibitor specific to KIT, prevents survival of CCDC26-KD cells under low-serum conditions. All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner. After ISCK03 treatment, the survival of KD cells is suppressed to the same level as that of non-KD cells. Conversely, ISCK03 treatment has limited effects on the growth of control K562 and KD clone 3–4 cells under high-serum concentration conditions.

體內(nèi)研究

Oral administration of ISCK03 induces the dose-dependent depigmentation of newly regrown hair, and this is reversed with cessation of ISCK03 treatment. The topical application of ISCK03 promotes the depigmentation of UV-induced hyperpigmented spots. Fontana-Masson staining analysis shows epidermal melanin is diminished in spots treated with ISCK03.

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