945526-43-2
基本信息
STEM-CELL FACTOR/C-KIT 抑制劑
ISCK 03
ISCK-03
C-KIT INHIBITOR II
Stem-Cell Factor/c-Kit Inhibitor
SteM-Cell Factor/c-Kit Inhibitor, ISCK03
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide
Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]
Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem
[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-101443 | STEM-CELL FACTOR/C-KIT 抑制劑 ISCK03 | 945526-43-2 | 5mg | 600元 |
2024/11/08 | HY-101443 | STEM-CELL FACTOR/C-KIT 抑制劑 ISCK03 | 945526-43-2 | 10mM * 1mLin DMSO | 660元 |
2024/11/08 | HY-101443 | STEM-CELL FACTOR/C-KIT 抑制劑 ISCK03 | 945526-43-2 | 10mg | 1000元 |
常見(jiàn)問(wèn)題列表
Target | Value |
SCF
() | |
c-Kit
() |
Pretreatment of 501mel cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream signaling. However ISCK03 does not inhibit hepatocyte growth factor (HGF)-induced phosphorylation of p44/42 ERK proteins. ISCK03, a tyrosine kinase inhibitor specific to KIT, prevents survival of CCDC26-KD cells under low-serum conditions. All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner. After ISCK03 treatment, the survival of KD cells is suppressed to the same level as that of non-KD cells. Conversely, ISCK03 treatment has limited effects on the growth of control K562 and KD clone 3–4 cells under high-serum concentration conditions.
Oral administration of ISCK03 induces the dose-dependent depigmentation of newly regrown hair, and this is reversed with cessation of ISCK03 treatment. The topical application of ISCK03 promotes the depigmentation of UV-induced hyperpigmented spots. Fontana-Masson staining analysis shows epidermal melanin is diminished in spots treated with ISCK03.