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94535-50-9

中文名稱 左色滿卡林
英文名稱 LEVCROMAKALIM
CAS 94535-50-9
分子式 C16H18N2O3
分子量 286.33
MOL 文件 94535-50-9.mol
94535-50-9 結(jié)構(gòu)式 94535-50-9 結(jié)構(gòu)式

基本信息

中文別名
左克羅卡林
左色滿卡林
英文別名
brl38227
lemakalim
Brn 3622889
levcromakelim
LEVCROMAKALIM
LevkroMakaliM
(3s-trans)-yrrolidinyl)
Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim
(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile

物理化學(xué)性質(zhì)

熔點(diǎn)242-244°
比旋光度D26 -52.2° (c = 1 in chloroform)
沸點(diǎn)482.3±45.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
儲(chǔ)存條件Store at RT
溶解度DMSO: ≤10 mM, soluble
溶解度DMSO:可溶≤10 mM
酸度系數(shù)(pKa)13.18±0.60(Predicted)
形態(tài)solid
顏色White to off-white

安全數(shù)據(jù)

安全說明22-24/25
WGK Germany3
WGK Germany3
RTECS號(hào)DJ2177500
左色滿卡林價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-14255左色滿卡林
Levcromakalim
94535-50-92 mg800元
2024/11/08HY-14255左色滿卡林
Levcromakalim
94535-50-95mg1200元
2024/11/08HY-14255左色滿卡林
Levcromakalim
94535-50-910 mM * 1 mLin DMSO1260元

常見問題列表

生物活性
Levcromakalim ((-)-Cromakalim) 是 ATP 敏感性的 K+ 通道 (KATP) 激活劑。
靶點(diǎn)

K + channel

體外研究

Levcromakalim ((-)-Cromakalim) inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 μM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 μM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control (n=5, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 μM) to 84±1.5% of the control (n=5; P<0.05). Levcromakalim (20 and 100 μM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control (n=6 and 4, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions by LevCromakalim (100 μM) to 79±3.5% of the control (n=4; P<0.05). Tonic contraction by OXT is also suppressed by Cromakalim in a glibenclamide-sensitive manner.The function of the K ATP channels is examined with the specific channel opener LevCromakalim (Cromakalim). LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); and there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10 -4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05).

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