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93908-02-2

中文名稱 蝴蝶霉素
英文名稱 REBECCAMYCIN
CAS 93908-02-2
分子式 C27H21Cl2N3O7
分子量 570.38
MOL 文件 93908-02-2.mol
93908-02-2 結(jié)構(gòu)式 93908-02-2 結(jié)構(gòu)式

基本信息

中文別名
蝴蝶霉素
瑞貝卡霉素
瑞貝卡霉素雜質(zhì)
英文別名
NSC 359079
REBECCAMYCIN
dro-12-(4-o-methyl-beta-d-glucopyranosyl)-
REBECCAMYCIN, SACCHAROTHRIX AEROCOLONIGENES
5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione,1,11-dichloro-12,13-dihy
1,11-Dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-
7,10-Dichloro-8-(3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-8,9-dihydro-1H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione

物理化學(xué)性質(zhì)

儲存條件−20°C
儲存條件−20°C
溶解度DMSO: ≥3 mg/mL
溶解度二甲基亞砜:≥3 mg/mL
形態(tài)solid
顏色yellow

安全數(shù)據(jù)

WGK Germany-
WGK Germany-

常見問題列表

生物活性
Rebeccamycin,一種抗腫瘤抗生素,抑制 DNA 拓?fù)洚悩?gòu)酶 I (DNA topoisomerase I)。Rebeccamycin 通過毒害拓?fù)洚悩?gòu)酶 I 發(fā)揮其主要的抗腫瘤作用,對蛋白激酶 C 和拓?fù)洚悩?gòu)酶 Ⅱ 的作用較小。
靶點(diǎn)

Topoisomerase I

Traditional Cytotoxic Agents

體外研究

Rebeccamycin is an antitumor antibiotic produced by the actinomycete Saccharotrix aerocolonigenes with activity against several human tumor cell lines, including A549 (lung adenocarcinoma), HCT-116 (colon carcinoma), and KB (nasopharyngeal carcinoma) .
Rebeccamycin shows antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis .

體內(nèi)研究

Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma, L1210 leukemia.

Animal Model: CDF1 mice (B16 melanoma, L1210 leukemia)
Dosage: 2, 4, 8, 16, 32, 64, 128, 256 mg/kg
Administration: I.p.; daily for 9 days
Result: Prolongation of survival of the mice at dose levels ranging from 8 to 256 mg/kg.
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