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934760-92-6

中文名稱 KD-3010
英文名稱 KD-3010
CAS 934760-92-6
分子式 C30H33F3N2O8S2
分子量 670.72
MOL 文件 934760-92-6.mol
934760-92-6 結(jié)構(gòu)式 934760-92-6 結(jié)構(gòu)式

基本信息

中文別名
化合物 T11747
英文別名
KD-3010

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

常見問題列表

生物活性
KD-3010 是一種具有口服活性的有效的選擇性 PPARδ 激動(dòng)劑。
靶點(diǎn)

PPARδ

體內(nèi)研究

To determine whether PPARδ agonists are beneficial in experimental liver fibrosis, mice are treated orally with a PPARδ agonist, KD-3010, or with the well-validated PPARδ agonist GW501516. KD-3010, but not GW501516, shows hepatoprotective and antifibrotic effects in liver fibrosis induced by carbon tetrachloride (CCl 4 ) or bile duct ligation (BDL). Liver injury is induced by repeated injections of CCl 4 , and mice are treated daily with vehicle, the widely used PPARδ agonist GW501516, or the PPARδ agonist KD-3010 by oral gavage. Control oil-injected mice do not show any liver damage. Liver injury consisting of hepatocyte death and inflammation is seen in the vehicle- or GW501516-treated group injected with CCl 4 on H&E-stained liver sections but is markedly reduced in the KD3010-treated group.

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