92439-20-8
92439-20-8 結(jié)構(gòu)式
基本信息
6,2'-二羥基黃酮
2',6-二羥基黃酮
2',6-二羥基黃酮,97%
2',6-DIHYDROXYFLAVONE
2',6-DIHYDROXYFLAVONE
6,2'-Dihydroxyflavone
6,2''-Dihydroxyflavone
6-hydroxy-2-(2-hydroxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 6-hydroxy-2-(2-hydroxyphenyl)-
6-hydroxy-2-(2-hydroxyphenyl)-4H-1-benzopyran-4-one, DHF
6,2'Dihydroxyflavone,Gamma-aminobutyric acid Receptor,γ-Aminobutyric acid Receptor,6,2'-Dihydroxyflavone,GABA Receptor,Inhibitor,inhibit,6,2' Dihydroxyflavone
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
GABA A receptor
6,2'-Dihydroxyflavone is a novel antagonist of GABA A receptor. 6,2'-Dihydroxyflavone inhibits [ 3 H]-flunitrazepam binding to the rat cerebral cortex membranes with a K i of 37.2±4.5 nM. The current elicited with the EC 50 concentration of GABA is decreased to 73.6±1.9% of control by co-application of 5 μM 6,2'-Dihydroxyflavone (n=5), compare to a decrease to 65.9±3.0% by 1 μM FG-7142 (n=5). The EC 50 for GABA dose response increases from 47.6 to 59.7 μM upon co-application of 5 μM 6,2'-Dihydroxyflavone, and the maximal GABA-current is decreased.
6,2'-Dihydroxyflavone-treated mice exhibit significant differences from control mice with respect to the percentage of open arms entries [F (4,73) =8.01, P<0.0001] and the percentage of time spent in open arms [F (4,73) =5.19, P<0.002], but not the number of entries to closed arms [F (4,73) = 0.79,P=0.54]. The post-hoc NewmaneKeuls’ tests confirm that 6,2'-Dihydroxyflavone significantly decreases the percentage of open arm entries and time spent in open arms at the doses of 8 and 16 mg/kg. 6,2'-Dihydroxyflavone treatment similarly increases step-through latency [F (4,75) =4.71, P<0.002], suggesting enhanced cognitive performance.